264272-64-2

Basic information

• Product Name: 4-(methoxycarbonyl)-3,5-dichlorobenzoic acid
• Synonyms: 4-(methoxycarbonyl)-3,5-dichlorobenzoic acid;3,5-dichloro-4-(methoxycarbonyl)benzoic acid
• CAS NO: 264272-64-2
• Molecular Formula: C₉H₆Cl₂O₄
• Molecular Weight: 249.04754
• Mol File: 264272-64-2.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• Solubility: DMF, DMSO, Methanol
• CAS DataBase Reference: 4-(methoxycarbonyl)-3,5-dichlorobenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(methoxycarbonyl)-3,5-dichlorobenzoic acid(264272-64-2)
• EPA Substance Registry System: 4-(methoxycarbonyl)-3,5-dichlorobenzoic acid(264272-64-2)

Safety Data

• Hazardous Substances Data: 264272-64-2(Hazardous Substances Data)

Usage

Description

4-(methoxycarbonyl)-3,5-dichlorobenzoic acid is an organic compound that serves as a key intermediate in the synthesis of various chemical compounds. It is characterized by the presence of a carboxylic acid group, two chlorine atoms, and a methoxycarbonyl group attached to a benzene ring. This unique structure endows it with specific chemical properties that make it valuable in the development of pharmaceuticals and agrochemicals.

Uses

Used in Pharmaceutical Industry:
4-(methoxycarbonyl)-3,5-dichlorobenzoic acid is used as a synthetic intermediate for the development of pharmaceutical compounds. Its versatile chemical structure allows for the creation of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
4-(methoxycarbonyl)-3,5-dichlorobenzoic acid is used as an intermediate in the synthesis of Zoxamide (Z700920), a fungicide specifically designed for the control of mildew and late blight in crops. Its role in the production of this fungicide highlights its importance in agricultural applications, where it helps protect plants from devastating diseases and ensures a stable food supply.

Upstream product

• 128-09-6 N-chloro-succinimide 
• 5372-81-6 dimethyl aminoterephthalate 
• 110-46-3 isopentyl nitrite 
• 264276-14-4 dimethyl 2,6-dichlorobenzene-1,4-dicarboxylate 
• 1258298-04-2 2-amino-3,5-dichloro-4-(carbomethoxy)benzoic acid methyl ester 
• 802616-47-3 2,6-dichloro-4-(methoxycarbonyl)benzoic acid 

Downstream Products

• 409127-35-1 4-tert-butoxycarbonylamino-2,6-dichloro-benzoic acid methyl ester 
• 409127-31-7 methyl 4-carbamoyl-2,6-dichlorobenzoate 
• 1415124-87-6 methyl 2,6-dichloro-4-(methylcarbamoyl)benzoate 
• 1415125-37-9 2,6-dichloro-4-(methylcarbamoyl)benzoic acid 
• 1415124-95-6 methyl 2,6-dichloro-4-(hydroxymethyl)benzoate 
• 1415123-49-7 3,5-dichloro-4-({7-[(cyclopropylcarbonyl)amino]-2-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl}carbonyl)-N-methylbenzamide 
• 1415125-25-5 2,6-dichloro-4-(methylcarbamoyl)benzoyl chloride 
• 1258295-23-6 2,6-dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)-4-(4H-1,2,4-triazol-3-yl)benzamide 
• 1438897-33-6 2,6-dichloro-N₁-(2-(cyclopropanecarboxamido)pyridin-4-yl)terephthalamide 
• 1258294-28-8 2,6-dichloro-4-cyano-N-(2-(cyclopropanecarboxamido)-pyridin-4-yl)benzamide 
• 1258298-05-3 2,6-dichloro-4-cyanobenzoic acid 
• 1258294-31-3 2,6-dichloro-4-cyano-N-(2-(1R,2R)-(2-fluorocyclopropanecarboxamido)pyridin-4-yl)benzamide 
• 1258294-30-2 2,6-dichloro-4-cyano-N-(2-((1S,2S)-2-fluorocyclopropanecarboxamido)pyridin-4-yl)benzamide 
• 1258298-06-4 2,6-dichloro-4-cyanobenzoyl chloride 

Relevant articles and documents

INHIBITORS OF ALPHA 2 BETA 1 INTEGRIN AND METHODS OF USE THEREOF

Disclosed herein, inter alia, are inhibitors of alpha 2 beta 1 integrin and methods of using the same.

Lead optimization of a 4-aminopyridine benzamide scaffold to identify potent, selective, and orally bioavailable TYK2 inhibitors

Herein we report our lead optimization effort to identify potent, selective, and orally bioavailable TYK2 inhibitors, starting with lead molecule 3. We used structure-based design to discover 2,6-dichloro-4-cyanophenyl and (1R,2R)-2-fluorocyclopropylamide modifications, each of which exhibited improved TYK2 potency and JAK1 and JAK2 selectivity relative to 3. Further optimization eventually led to compound 37 that showed good TYK2 enzyme and interleukin-12 (IL-12) cell potency, as well as acceptable cellular JAK1 and JAK2 selectivity and excellent oral exposure in mice. When tested in a mouse IL-12 PK/PD model, compound 37 showed statistically significant knockdown of cytokine interferon-γ (IFNγ), suggesting that selective inhibition of TYK2 kinase activity might be sufficient to block the IL-12 pathway in vivo.

JANUS KINASE INHIBITOR COMPOUNDS AND METHODS

The invention provides compounds of Formula I, stereoisomers or pharmaceutically acceptable salts thereof, wherein A, B, D, R1, R2, R4 and R5 are defined herein, a pharmaceutical composition that includes a compound of Formula I and methods of use thereof