264624-38-6 Usage
Description
27-Deoxyactein is a triterpene glycoside and a derivative of Actein (A191800), which is a gamma secretase modulator derived from botanicals. It is a major constituent of black cohosh (C. racemosa) and has demonstrated various biological activities, including the stimulation of osteoblast function and inhibition of bone resorbing mediators, making it a potential candidate for the treatment of osteoporosis.
Uses
Used in Pharmaceutical Industry:
27-Deoxyactein is used as a therapeutic agent for the treatment of osteoporosis. It stimulates osteoblast function and inhibits bone resorbing mediators, which can help in the management and prevention of bone loss associated with osteoporosis.
Used in Research Applications:
27-Deoxyactein is used as a research tool for studying the effects of gamma secretase modulators on cellular processes. Its ability to reduce intracellular calcium concentrations, collapse of the mitochondrial membrane potential, production of reactive oxygen species (ROS), and cardiolipin peroxidation, as well as its inhibition of autophagy and apoptosis, make it a valuable compound for investigating the underlying mechanisms of various diseases and conditions.
Used in Drug Development:
As a derivative of Actein, 27-Deoxyactein can be used in the development of new drugs targeting gamma secretase, which plays a crucial role in the pathogenesis of several diseases, including Alzheimer's disease and certain cancers. Its potential applications in drug development could lead to the discovery of novel therapeutic agents with improved efficacy and reduced side effects.
Check Digit Verification of cas no
The CAS Registry Mumber 264624-38-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,6,4,6,2 and 4 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 264624-38:
(8*2)+(7*6)+(6*4)+(5*6)+(4*2)+(3*4)+(2*3)+(1*8)=146
146 % 10 = 6
So 264624-38-6 is a valid CAS Registry Number.