26491-49-6

Basic information

• Product Name: 1H-Isoindole-1,3(2H)-dione, 5-chloro-2-phenyl-
• Synonyms: 4-chloro-N-phenylphthalimide;5-Chlor-2-phenyl-isoindolin-1,3-dion;N-phenyl-4-chlorophthalimide;1H-Isoindole-1,3(2H)-dione,5-chloro-2-phenyl;5-chloro-2-phenyl-isoindole-1,3-dione;4-Chlor-N-phenylphthalimid
• CAS NO: 26491-49-6
• Molecular Formula: C14H8ClNO2
• Molecular Weight: 257.676
• Mol File: 26491-49-6.mol
• Article Data: 12

Chemical Properties

• Melting Point: 213-216 °C
• Boiling Point: 431.6±47.0 °C(Predicted)
• Density: 1.441±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 1H-Isoindole-1,3(2H)-dione, 5-chloro-2-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Isoindole-1,3(2H)-dione, 5-chloro-2-phenyl-(26491-49-6)
• EPA Substance Registry System: 1H-Isoindole-1,3(2H)-dione, 5-chloro-2-phenyl-(26491-49-6)

Safety Data

• Hazardous Substances Data: 26491-49-6(Hazardous Substances Data)

Upstream product

• 19202-05-2 N-(4-chlorobenzoyl)pyrrolidine 
• 103-71-9 phenyl isocyanate 
• 1197040-29-1 phenyl isocyanate 
• 13421-00-6 5-chloro-2-iodo-benzoic acid 
• 42348-86-7 5-chloro-1-indanone 
• 62-53-3 aniline 
• 118-45-6 4-chlorophthalic anhydride 
• 119072-55-8 tert-butylisonitrile 
• 57381-49-4 2-bromo-4-chloro-benzonitrile 
• 74-11-3 para-chlorobenzoic acid 
• 635-21-2 5-chloroanthranilic acid 
• 201230-82-2 carbon monoxide 
• 1608-45-3 4-chloro-1,2,-diiodobenzene 

Downstream Products

• 3348-10-5 N-phenyl-4-(carboxyanilino)phthalimide 
• 2420-87-3 3,3',4,4'-biphenyltetracarboxylic anhydride 
• 22803-05-0 4,4'-biphthalic acid 
• 36978-40-2 2,3,3′,4′-biphenyl tetracarboxylic dianhydride 
• 36978-41-3 2,3',3,4'-biphenyltetracarboxylic acid dianhydride 
• 58974-89-3 4,4'-bis(N-phenylphthalimide)sulfide 

Relevant articles and documents

Synthesis of imides via palladium-catalyzed three-component coupling of aryl halides, isocyanides and carboxylic acids

A palladium-catalyzed three-component synthesis of acyclic imides from feedstock aryl halides, carboxylic acids and isocyanides through the intermediacy of isoimides has been developed. The key to the success of this approach was controlled isocyanide slow addition and organic/aqueous biphasic conditions. This transition-metal-catalyzed approach features readily available starting materials, atom- and step-economy, good functional group compatibility and gram-scale synthetic capability. Utilization of this new method is illustrated in the late-stage functionalization of drugs Carprofen, Loxoprofen and Flurbiprofen. This strategy has also been successfully applied in the synthesis of cyclic imides including phthalimide, homophthalimide, and 2H-2-benzazepine-1,3-dione derivatives.

Palladium-Catalyzed Synthesis of 1H-Indenes and Phthalimides via Isocyanide Insertion

A new and versatile multicomponent domino strategy has been developed for the synthesis of a series of 1H-indene and phthalimide derivatives from simple and readily available starting materials. This process operating under mild conditions shows a broad substrate scope with moderate to excellent yields.

Visible-light induced isoindoles formation to trigger intermolecular diels-alder reactions in the presence of air

Visible-light induced isoindole formation triggered an intermolecular Diels-Alder reaction with dienophiles such as acetylenedicarboxylate and maleimides in the presence of air. The reaction resulted in excellent diastereoselctivity and high yields under