265137-38-0

Basic information

• Product Name: 4,4-dimethyl-[2-[3-hydroxymethyl-4-[4-fluoro-a-hydroxy-a-(dimethylamino)propyl]benzyl]phenyl]oxazoline
• Synonyms: 4,4-dimethyl-[2-[3-hydroxymethyl-4-[4-fluoro-a-hydroxy-a-(dimethylamino)propyl]benzyl]phenyl]oxazoline
• CAS NO: 265137-38-0
• Molecular Weight: 414.52
• Mol File: 265137-38-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4,4-dimethyl-[2-[3-hydroxymethyl-4-[4-fluoro-a-hydroxy-a-(dimethylamino)propyl]benzyl]phenyl]oxazoline(CAS DataBase Reference)
• NIST Chemistry Reference: 4,4-dimethyl-[2-[3-hydroxymethyl-4-[4-fluoro-a-hydroxy-a-(dimethylamino)propyl]benzyl]phenyl]oxazoline(265137-38-0)
• EPA Substance Registry System: 4,4-dimethyl-[2-[3-hydroxymethyl-4-[4-fluoro-a-hydroxy-a-(dimethylamino)propyl]benzyl]phenyl]oxazoline(265137-38-0)

Safety Data

• Hazardous Substances Data: 265137-38-0(Hazardous Substances Data)

Upstream product

• 19070-16-7 3-(N,N-dimethylamino)propylmagnesium chloride 
• 265137-37-9 4,4-dimethyl-2-(1-oxo-1,3-dihydroisobenzofuran-5-yl)oxazoline 
• 352-13-6 4-flourophenylmagnesium bromide 

Downstream Products

• 59729-33-8 1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile 
• 265137-39-1 4,4-dimethyl-2-[1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-yl]oxazoline 

Relevant articles and documents

Process for the preparation of citalopram

Preparation of citalopram comprises the steps of: (a) converting the compound of Formula (I) to a compound of Formula (II), wherein R in Formula (I) represents a C2 to C5 alkylene group which may be substituted or unsubstituted, and R1 in the compounds of Formula (II) represents a carboxylic acid group or a salt or an ester thereof; and (b) converting the compound of Formula (II) to form citalopram or a pharmaceutically acceptable salt thereof, or a direct conversion of the compound of Formula (I) to citalopram