2653-93-2 Usage
Uses
Safrole is used primarily in the manufacture of perfumes, soaps, and flavorings, as well as in some pesticide formulations.
Recreational Drug Production
Safrole is an intermediate in the production of the recreational drug MDMA (ecstasy).
Potential Carcinogenicity
The use of safrole in food and drugs is strictly regulated due to concerns about its potential carcinogenicity.
Illegal Drug Synthesis
Safrole has been identified as a precursor in the synthesis of the illegal drugs MDA (3,4-methylenedioxyamphetamine) and MDEA (3,4-methylenedioxyethylamphetamine).
Banned or Restricted
Due to its potential health risks and connections to illegal drug production, safrole has been banned or heavily restricted in many countries.
Check Digit Verification of cas no
The CAS Registry Mumber 2653-93-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,6,5 and 3 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 2653-93:
(6*2)+(5*6)+(4*5)+(3*3)+(2*9)+(1*3)=92
92 % 10 = 2
So 2653-93-2 is a valid CAS Registry Number.
InChI:InChI=1/C15H14O/c1-2-6-13-9-11-15(12-10-13)16-14-7-4-3-5-8-14/h2-5,7-12H,1,6H2
2653-93-2Relevant articles and documents
Palladium-catalyzed prenylation of (hetero)aryl boronic acids
Leister, Jeffrey,Chao, Darrian,Billingsley, Kelvin L.
supporting information, (2021/02/09)
Prenyl or dimethylallyl groups are common structural motifs in natural products and small molecule therapeutics. In this report, we describe a palladium-catalyzed method for the cross-coupling of aryl and heteroaryl boronic acids with prenyl alcohol. Catalyst systems based on dialkylbiaryl phosphines were highly active for this transformation. These supporting ligands provided opportunities for tuning the efficiency and regioselectivity of carbon–carbon bond formation. In addition, this method was further extended to the cross-coupling of symmetrical allylic alcohols with aryl boronic acids.
