26570-48-9Relevant articles and documents
A facile approach to bis(Isoxazoles), promising ligands of the ampa receptor
Averina, Elena B.,Grigoriev, Vladimir V.,Grishin, Yuri K.,Karlov, Dmitry S.,Kuznetsova, Tamara S.,Palyulin, Vladimir A.,Radchenko, Eugene V.,Rybakov, Victor B.,Sadovnikov, Kirill S.,Sedenkova, Kseniya N.,Vasilenko, Dmitry A.,Zamoyski, Vladimir L.
, (2021/11/01)
A convenient synthetic approach to novel functionalized bis(isoxazoles), the promising bivalent ligands of the AMPA receptor, was elaborated. It was based on the heterocyclization reactions of readily available electrophilic alkenes with the tetranitromethane-triethylamine complex. The structural diversity of the synthesized compounds was demonstrated. In the electrophysi-ological experiments using the patch clamp technique on Purkinje neurons, the compound 1,4-phenylenedi(methylene)bis(5-aminoisoxazole-3-carboxylate) was shown to be highly potent positive modulator of the AMPA receptor, potentiating kainate-induced currents up to 70% at 10?11 M.
Method for synthesizing (methyl) acrylate glyceride through catalysis of calcium glyceroxide
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Paragraph 0041; 0042, (2017/09/14)
The invention discloses a method for synthesizing (methyl) acrylate glyceride through catalysis of calcium glyceroxide and belongs to the field of fine chemical engineering. The method comprises the steps that a reaction-rectification technology is adopted, a refit rectification column filled with copper wire gauze is used, and alkyl (meth) acrylate, glycerol, a polymerization inhibitor and a catalyst are added; under the string condition, air is introduced, and heating is carried out until a reaction solution flows back, wherein the temperature ranges from 60 DEG C to 140 DEG C; after the reaction is finished, a reaction solution is cooled to 50 DEG C, active carbon is added, stirring is continuously carried out for 0.5-1 h with the temperature maintained, the reaction solution is subjected to pressure reduction suction filtration after the reaction is finished, filter liquor is subjected to pressure reduction rotary steaming to remove the excessive raw material ester, and the (methyl) acrylate glyceride reactive diluent product is obtained. The method overcomes the defects of an existing ester exchange catalyst, and is high in yield, simple in aftertreatment and easy to implement.
Method for catalytically synthesizing diethylene glycol di(methyl) acrylate by calcium glyceroxide
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Paragraph 0041; 0042, (2017/01/02)
The invention discloses a method for catalytically synthesizing diethylene glycol di(methyl) acrylate by calcium glyceroxide, and belongs to the field of fine chemical engineering. (Methyl) alkyl acrylate and diethylene glycol are used as raw materials; a reaction-rectification coupling process is adopted; a copper-wire-net-filled modified rectification column is used; the catalyst calcium glyceroxide is added; enough product purity and yield can be obtained after a simple aftertreatment process. The method overcomes multiple disadvantages of an existing transesterification catalyst, and is high in yield and simple in post-processing. Compared with a conventional transesterification method, the method provided by the invention can improve the total yield and the processing capacity; energy needed for separation is supplied by utilizing reaction heat, so that the energy consumption is decreased, and an investment is reduced. The method provided by the invention is simple and short in process flow; the raw materials are easily obtained; equipment is simple; reaction conditions are easy to control. The method is mild in the reaction conditions and simple in purification and refining processes; a product is stable, is easy to separate, and is not liable to generate a polymerization phenomenon.
