26591-66-2Relevant articles and documents
Synthesis, characterization, molecular structure determination by single crystal X-ray diffraction, and Hirshfeld surface analysis of 7-fluoro-6-morpholino-3-phenylquinolin-1-ium chloride salt and computational studies of its cation
Allikayala, Ramachandraiah,Thandra, Dhananjay Rao
, (2021/11/08)
7-fluoro-6-morpholino-3-phenylquinolin-1-ium chloride 2 has been synthesized and characterised by various spectral and electrochemical studies besides its molecular structure determination by a single-crystal X-ray diffraction investigation. Computational studies by Austin Model-1 (AM1), SCF-MM2 and DFT/B3LYP to compare the structural data with the single crystal XRD data have been performed on the cation of 2. The compound is found to crystallize in a monoclinic system in space group P21/c with crystal data as a = 11.0497(4) ?, b = 8.8712 (3) ?, c = 17.5099 (5) ?, β = β = 97.605 (17), V = 1701.3 (10) ?3, Z = 4, density = 1.346 Mg/m3, F (000) = 720, T = 293 K. Hirshfeld surface plots and fingerprint plots are obtained on 2 which show hydrogen bond intermolecular interactions. Electrochemical studies reveal that 2 undergoes diffusion-controlled irreversible anodic electron transfer and that it fluoresces at 520 nm with an absorption at ～ 430 nm. The molecular docking of 2 on EGFR-TK protein and its cell viability assay on hypopharyngeal cancer cell line (FaDu) through MTT assay promise a scope of using compound 2 as an anticancer drug.
S - Cis Diene Conformation: A New Bathochromic Shift Strategy for Near-Infrared Fluorescence Switchable Dye and the Imaging Applications
Chen, Hsiang-Jung,Chew, Chee Ying,Chang, En-Hao,Tu, Yu-Wei,Wei, Li-Yu,Wu, Bo-Han,Chen, Chien-Hung,Yang, Ya-Ting,Huang, Su-Chin,Chen, Jen-Kun,Chen, I-Chia,Tan, Kui-Thong
supporting information, p. 5224 - 5234 (2018/04/23)
In this paper, we present a novel charge-free fluorescence-switchable near-infrared (IR) dye based on merocyanine for target specific imaging. In contrast to the typical bathochromic shift approach by extending π-conjugation, the bathochromic shift of our merocyanine dye to the near-IR region is due to an unusual S-cis diene conformer. This is the first example where a fluorescent dye adopts the stable S-cis conformation. In addition to the novel bathochromic shift mechanism, the dye exhibits fluorescence-switchable properties in response to polarity and viscosity. By incorporating a protein-specific ligand to the dye, the probes (for SNAP-tag and hCAII proteins) exhibited dramatic fluorescence increase (up to 300-fold) upon binding with its target protein. The large fluorescence enhancement, near-IR absorption/emission, and charge-free scaffold enabled no-wash and site-specific imaging of target proteins in living cells and in vivo with minimum background fluorescence. We believe that our unconventional approach for a near-IR dye with the S-cis diene conformation can lead to new strategies for the design of near-IR dyes.
Synthesis, anticancer activity and DNA-binding properties of novel 4-pyrazolyl-1,8-naphthalimide derivatives
Li, Shenghui,Xu, Shengjie,Tang, Yonghe,Ding, Shan,Zhang, Jinchao,Wang, Shuxiang,Zhou, Guoqiang,Zhou, Chuanqi,Li, Xiaoliu
supporting information, p. 586 - 590 (2014/01/23)
A novel series of 4-pyrazolyl-1,8-naphthalimide derivatives have been designed and facilely synthesized. For anticancer activity in vitro, most of the compounds were found to be more toxic against human mammary cancer cells (MCF-7) than human cervical car
