265980-87-8

Basic information

• Product Name: monoethyl suberate [4-3H]anilide
• CAS NO: 265980-87-8
• Molecular Weight: 279.356
• Mol File: 265980-87-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: monoethyl suberate [4-3H]anilide(CAS DataBase Reference)
• NIST Chemistry Reference: monoethyl suberate [4-3H]anilide(265980-87-8)
• EPA Substance Registry System: monoethyl suberate [4-3H]anilide(265980-87-8)

Safety Data

• Hazardous Substances Data: 265980-87-8(Hazardous Substances Data)

Upstream product

• 265980-86-7 monoethyl suberate 4-bromoanilide 
• 14113-02-1 ethyl 8-chloro-8-oxooctanoate 
• 14113-01-0 Ethyl hydrogen suberate 

Relevant articles and documents

An efficient synthesis of N-hydroxy-N'-[4-3H]phenyloctanediamide ([4-3H]SAHA), a potent cytodifferentiating agent

We have developed an efficient synthesis of N-hydroxy-N'-[4-3H]phenyloctanediamide ([4-3H]SAHA) from the monoester of suberanilic acid. The starting material, a monoester of suberoyl chloride, was condensed with 4-bromoaniline in the presence of a base to give the 4-bromoanilide of monoethyl suberate in 92% yield. On further treatment with methanolic hydroxylamine hydrochloride and sodium methoxide, this compound gave 4-bromosuberanilohydroxamic acid in 94% yield. Catalytic tritium exchange of bromine using Pd/C in a tritium gas atmosphere resulted in [4-3H]SAHA with a specific activity of 2.49 Ci/mmol. From the key intermediate, 4-bromoanilide of monoethyl suberate by a non-catalytic tritium exchange reaction, we have also prepared [4-3H]SAHA with high specific activity of 27.5 Ci/mmol.