265989-31-9

Basic information

• Product Name: N-2-BENZYLOXYPHENYL ISOBUTYRYLACETAMIDE
• Synonyms: N-2-BENZYLOXYPHENYL ISOBUTYRYLACETAMIDE;4-Methyl-3-oxo-N-[2-(phenylMethoxy)phenyl]pentanaMide;4-Methyl-3-oxopentanoic acid N-(2-Benzyloxyphenyl)aMide
• CAS NO: 265989-31-9
• Molecular Formula: C₁₉H₂₁NO₃
• Molecular Weight: 311.37
• Product Categories: Aromatics Compounds;Aromatics
• Mol File: 265989-31-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 488.808°C at 760 mmHg
• Flash Point: 249.423°C
• Appearance: /
• Density: 1.15g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.581
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
• CAS DataBase Reference: N-2-BENZYLOXYPHENYL ISOBUTYRYLACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-2-BENZYLOXYPHENYL ISOBUTYRYLACETAMIDE(265989-31-9)
• EPA Substance Registry System: N-2-BENZYLOXYPHENYL ISOBUTYRYLACETAMIDE(265989-31-9)

Safety Data

• Hazardous Substances Data: 265989-31-9(Hazardous Substances Data)

Usage

Chemical Properties

Brown Solid

InChI:InChI=1/C19H21NO3/c1-14(2)17(21)12-19(22)20-16-10-6-7-11-18(16)23-13-15-8-4-3-5-9-15/h3-11,14H,12-13H2,1-2H3,(H,20,22)

Upstream product

• 186663-07-0 tert-butyl (2-(benzyloxy)phenyl)carbamate 
• 186663-74-1 tert-butyl (2-hydroxyphenyl)carbamate 
• 95-55-6 2-amino-phenol 
• 20012-63-9 o-(benzyloxy)aniline 
• 42558-54-3 Methyl 4-methyl-3-oxopentanoate 
• 4560-41-2 2-benzyloxynitrobenzene 

Downstream Products

• 1020719-18-9 C₂₆H₂₀⁽²⁾H₅NO₃ 
• 163217-77-4 4-Methyl-3-oxo-2-[1-phenyl-meth-(Z)-ylidene]-pentanoic acid (2-benzyloxy-phenyl)-amide 
• 887355-33-1 4-methyl-3-oxo-N-(2-benzyloxyphenyl)-2-[1-phenyl-2-(4-fluorophenyl)-2-oxoethyl]pentanamide 
• 265989-41-1 C₄₇H₄₈⁽²⁾H₅FN₂O₆ 
• 265989-42-2 C₄₀H₄₂⁽²⁾H₅FN₂O₆ 
• 777841-55-1 C₃₃H₃₀⁽²⁾H₅FN₂O₆ 
• 265989-50-2 C₃₃H₂₈⁽²⁾H₅FN₂O₅ 
• 265989-39-7 (4R-cis)-1,1-dimethylethyl-6-[2-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(4-benzyloxyphenyl)carbonyl]-1H-pyrrol-yl]ethyl]-2,2-dimethyl-1,3-dioxane-4-acetate 
• 265989-40-0 ((4R,6R)-6-{2-[2-(4-Fluoro-phenyl)-4-(2-hydroxy-phenylcarbamoyl)-5-isopropyl-3-phenyl-pyrrol-1-yl]-ethyl}-2,2-dimethyl-[1,3]dioxan-4-yl)-acetic acid tert-butyl ester 
• 1346599-89-0 (3R,5R)-7-[2-(4-Fluoro-phenyl)-4-(2-hydroxy-phenylcarbamoyl)-5-isopropyl-3-phenyl-pyrrol-1-yl]-3,5-dihydroxy-heptanoic acid tert-butyl ester 
• 214217-86-4 o-Hydroxyatorvastatin 
• 1020719-43-0 C₃₃H₂₅⁽²⁾H₅FNO₄ 
• 163217-74-1 o-Hydroxyatorvastatin lactone 

Relevant articles and documents

IMPROVED PROCESS FOR THE PREPARATION OF [3R,5R]-2-FLUOROPHENYL-β,δ- DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-[(2-HYDROXYPHENYLAMINO)- CARBONYL]-1H-PYRROLE-1-HEPTANOIC ACID, SODIUM SALT

The present invention relates to an improved process for the preparation of [3R,5R]-2-fluorophenyl-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(2-hydroxyphenylamino)-carbonyl]-1H-pyrrole-1-heptanoic acid sodium salt compound of formula- 1 represented by the following structural formula:

Synthesis of deuterium-labeled atorvastatin and its metabolites for use as internal standards in a LC/MS/MS method developed for quantitation of the drug and its metabolites in human serum

D5-labeled isotopomers of atorvastatin, atorvastatin lactone and its hydroxy metabolites were synthesized as internal standards for use in a LC/MS/MS method developed for the simultaneous quantitative determination of atorvastatin and its hydroxy metabolites in human serum. d5-Atorvastatin and d5-atorvastatin lactone were prepared from d5-aniline whereas their corresponding hydroxy metabolites were synthesized using d5-benzaldehyde.