26628-87-5Relevant articles and documents
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Gribble
, p. 1833 (1972)
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Oxidative Pictet-Spengler cyclisations through acceptorless iridium-catalysed dehydrogenation of tertiary amines
Cooksey, John P.,Saidi, Ourida,Williams, Jonathan M.J.,Blacker, A. John,Marsden, Stephen P.
, (2020/12/14)
The valuable tetrahydro-β- and γ-carboline skeleta can be accessed through Pictet-Spengler cyclisation initiated by acceptorless dehydrogenation of saturated cyclic amines. The substrate scope for the β-isomers is found to be somewhat limited, but access
N-Alkylation of phenethylamine and tryptamine
Cami-Kobeci, Gerta,Slatford, Paul A.,Whittlesey, Michael K.,Williams, Jonathan M.J.
, p. 535 - 537 (2007/10/03)
A clean and efficient method for the N-alkylation of tryptamine and phenethylamine, employing alcohols as the alkylating agents, has been developed. The reaction proceeds via catalytic electronic activation, involving an iridium catalyst which activates the alcohol by borrowing hydrogen from the substrate, returning it later in the catalytic cycle. Some examples of N-heterocyclisation have been performed employing a diol as the substrate.
RUTHENIUM CATALYZED SYNTHESIS OF TERTIARY AMINES FROM AMINES AND ALCOHOLS
Murahashi, Shun-Ichi,Kondo, Kaoru,Hakata, Toshiyuki
, p. 229 - 232 (2007/10/02)
Unsymmetrical secondary and tertiary amines are prepared by the ruthenium catalyzed reaction of alcohols with amines, which provides highly efficient method for synthesis of cyclic amines.
