266694-67-1

Basic information

• Product Name: Benzoic acid (R)-3-hydroxy-3-((2R,4aR,7R,8aR)-4,4,7-trimethyl-hexahydro-1-oxa-3-thia-naphthalen-2-yl)-butyl ester
• Synonyms: Benzoic acid (R)-3-hydroxy-3-((2R,4aR,7R,8aR)-4,4,7-trimethyl-hexahydro-1-oxa-3-thia-naphthalen-2-yl)-butyl ester
• CAS NO: 266694-67-1
• Molecular Weight: 392.56
• Mol File: 266694-67-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzoic acid (R)-3-hydroxy-3-((2R,4aR,7R,8aR)-4,4,7-trimethyl-hexahydro-1-oxa-3-thia-naphthalen-2-yl)-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid (R)-3-hydroxy-3-((2R,4aR,7R,8aR)-4,4,7-trimethyl-hexahydro-1-oxa-3-thia-naphthalen-2-yl)-butyl ester(266694-67-1)
• EPA Substance Registry System: Benzoic acid (R)-3-hydroxy-3-((2R,4aR,7R,8aR)-4,4,7-trimethyl-hexahydro-1-oxa-3-thia-naphthalen-2-yl)-butyl ester(266694-67-1)

Safety Data

• Hazardous Substances Data: 266694-67-1(Hazardous Substances Data)

Upstream product

• 98-88-4 benzoyl chloride 
• 111998-90-4 (R)-3-((2R,4aR,7R,8aR)-4,4,7-Trimethyl-hexahydro-1-oxa-3-thia-naphthalen-2-yl)-butane-1,3-diol 

Downstream Products

• 1192-42-3 (R)-2-methyl-2-hydroxy-γ-butyrolactone 

Relevant articles and documents

Enantioselective syntheses of substituted γ-butyrolactones

The previously described chiral 2-acyloxathianes 5 (Scheme I) are used in two different enantioselective syntheses of γ-butyrolactones. In one synthesis, Grignard addition, cleavage and reduction to carbinols RR'C(OH)CH2OH is followed by tosylation, malonate homologation, lactonization, and removal of the carbomethoxy group to give optically active γ-lactones. A modification of this synthesis (Scheme I) leads to optically active α-methylene-γ-lactones. In the second synthesis, reaction of a bromomagnesium enolate with ketones 5 leads to β-hydroxyesters, which, by appropriate sequences of reduction and cleavage (Scheme II) are converted to optically active α- or β-hydroxy-γ-lactones.