2671-68-3Relevant articles and documents
About the mechanism of sterol biosynthesis
Krief,Schauder,Guittet,Herve du Penhoat,Lallemand
, p. 7910 - 7911 (1987)
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Synthesis of Lanostane-Type Triterpenoid N-Glycosides and Their Cytotoxicity against Human Cancer Cell Lines
Ukiya, Motohiko,Hayakawa, Teppei,Okazaki, Kouta,Hikawa, Maiko,Akazawa, Hiroyuki,Li, Wei,Koike, Kazuo,Fukatsu, Makoto
, (2018/07/13)
Seventeen lanostane-type triterpenoid derivatives (2 – 18), including 11N-glycosides (8 – 18), were synthesized from the natural triterpenoid, lanosterol (1), and were evaluated for their cytotoxicity against the human cancer cell lines, HL-60, A549, and MKN45, as well as the normal human lung cells, WI-38. Among them, N-β-d-2-acetamido-2-deoxyglucoside (10) showed cytotoxicity against HL-60, A549, MKN45, and WI-38 cells (IC50 0.0078 – 2.8 μm). However, N-β-d-galactoside (12) showed cytotoxicity against HL-60 and MKN45 cells (IC50 0.0021 – 4.0 μm), but not the normal WI-38 cells. Furthermore, Western blot analysis suggested that 12 induces apoptosis by activation of caspases-3, 8, and 9. These results will be useful for the synthesis of other tetracyclic triterpenoids or steroid N-glycosides to increase their cytotoxicity and apoptosis-inducing activities.
Total Synthesis of Echinoside A, a Representative Triterpene Glycoside of Sea Cucumbers
Chen, Xiaoping,Shao, Xiaofei,Li, Wei,Zhang, Xiaheng,Yu, Biao
supporting information, p. 7648 - 7652 (2017/06/13)
Echinoside A, a sulfonylated holostane tetrasaccharide with potent anticancer and antifungal activity, was synthesized in a longest linear sequence of 35 steps and 0.6 % overall yield. The synthetic approach is adaptable to the synthesis of congeners and analogues, as exemplified by the ready synthesis of ds-echinoside A and echinoside B, and thus will facilitate in-depth studies on the promising biological effects of echinoside A. Moreover, the present synthesis demonstrates the feasibility of synthetic access to the characteristic complex triterpene glycosides that occur ubiquitously in sea cucumbers.
Commands and method of treating cancer via RHO pathway
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Paragraph 0043, (2016/02/03)
Lanosterol derivatives useful as anti-cancer agent, which can inhibit the growth of lung cancer cells, liver cancer cells, mammary cancer cells, brain cancer cells and pancreatic cancer cells, possibly by acting on the RHO pathway. These lanosterol derivatives are represented by compound LD030:
