267228-41-1

Basic information

• Product Name: latifolicinin B
• Synonyms: latifolicinin B
• CAS NO: 267228-41-1
• Molecular Weight: 210.23
• Mol File: 267228-41-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: latifolicinin B(CAS DataBase Reference)
• NIST Chemistry Reference: latifolicinin B(267228-41-1)
• EPA Substance Registry System: latifolicinin B(267228-41-1)

Safety Data

• Hazardous Substances Data: 267228-41-1(Hazardous Substances Data)

Upstream product

• 64-17-5 ethanol 
• 23508-35-2 (S)-2-hydroxy-3-(4-hydroxy-phenyl)-propionic acid 
• 156-39-8 4-hydroxyphenylpiruvic acid 
• 267228-40-0 3-(4-benzyloxyphenyl)-2-hydroxypropionic acid ethyl ester 

Relevant articles and documents

Latifolicinin A from a Fermented Soymilk Product and the Structure-Activity Relationship of Synthetic Analogues as Inhibitors of Breast Cancer Cell Growth

The functional components in soymilk may vary depending upon the fermentation process. A fermented soymilk product (FSP) obtained by incubation with the microorganisms of intestinal microflora was found to reduce the risk of breast cancer. Guided by the inhibitory activities against breast cancer cells, two cytotoxic compounds, daidzein and (S)-latifolicinin A, were isolated from the FSP by repetitive extraction and chromatography. Latifolicinin A is the n-butyl ester of β-(4-hydroxyphenyl)lactic acid (HPLA). A series of the ester and amide derivatives of (S)-HPLA and l-tyrosine were synthesized for evaluation of their cytotoxic activities. In comparison, (S)-HPLA derivatives exhibited equal or superior inhibitory activities to their l-tyrosine counterparts, and (S)-HPLA amides showed better cytotoxic activities than their corresponding esters. In particular, (S)-HPLA farnesyl amide was active to triple-negative MDA-MB-231 breast cancer cells (IC50 = 27 μM) and 10-fold less toxic to Detroit-551 normal cells.