267243-86-7

Basic information

• Product Name: ETHYL 2-TRIFLUOROACETYL-3-(N,N-DIMETHYLAMINO)-2-PROPENOATE
• Synonyms: ETHYL 2-TRIFLUOROACETYL-3-(N,N-DIMETHYLAMINO)-2-PROPENOATE
• CAS NO: 267243-86-7
• Molecular Formula: C₉H₁₂F₃NO₃
• Molecular Weight: 239.19
• Mol File: 267243-86-7.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 194.516°C at 760 mmHg
• Flash Point: 71.441°C
• Appearance: /
• Density: 1.228g/cm³
• Vapor Pressure: 0.44mmHg at 25°C
• Refractive Index: 1.423
• CAS DataBase Reference: ETHYL 2-TRIFLUOROACETYL-3-(N,N-DIMETHYLAMINO)-2-PROPENOATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 2-TRIFLUOROACETYL-3-(N,N-DIMETHYLAMINO)-2-PROPENOATE(267243-86-7)
• EPA Substance Registry System: ETHYL 2-TRIFLUOROACETYL-3-(N,N-DIMETHYLAMINO)-2-PROPENOATE(267243-86-7)

Safety Data

• Hazardous Substances Data: 267243-86-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H12F3NO3/c1-4-16-8(15)6(5-13(2)3)7(14)9(10,11)12/h5H,4H2,1-3H3/b6-5-

Upstream product

• 354-32-5 trifluoracetyl chloride 
• 924-99-2 ethyl 3-(dimethylamino)acrylate 
• 76-05-1 trifluoroacetic acid 
• 407-25-0 trifluoroacetic anhydride 
• 18503-89-4 N,N-dimethylformamide diisopropyl acetal 
• 372-31-6 ethyl 4,4,4-trifluoroacetoacetate 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 

Downstream Products

• 134653-70-6 ethyl 2-[(dimethylamino)methylene]-3-oxobutanoate 
• 175137-38-9 ethyl 1-(4-fluorophenyl)-5-trifluoromethyl-4-pyrazolecarboxylate 
• 1190236-37-3 ethyl 5-(trifluoromethyl)-1-({4-[3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}methyl)-1H-pyrazole-4-carboxylate 

Relevant articles and documents

Continuous preparation method of trifluoromethyl butenone derivative

The invention discloses a continuous preparation method of a trifluoromethyl butenone derivative. The continuous preparation method is characterized in that a raw material 1 as shown in a structure (I) in a reaction formula and trifluoroacetyl halide serving as a raw material 2 react in a microchannel reactor to prepare the trifluoromethyl butenone derivative as shown in a structure (II). The structure (I) and the structure (II) are as described in the specification. In the structure (I) and the structure (II), R is an electron donating group and can be conjugated with olefin double bonds; R1 and R2 are independently selected from hydrogen, C1-C20 alkyl groups, aryl groups, and substituted aryl groups or silyl groups; and X is halogen and is selected from fluorine, chlorine, bromine and iodine. The method has the advantages of good process universality, good atom economy, high yield, few byproducts, high product purity and the like.

1-(4-(ISOXAZOL-5-YL)-1H-PYRAZOL-1-YL)-2-METHYLPROPAN-2-OL DERIVATIVES AND RELATED COMPOUNDS AS IL-17 AND IFN-GAMMA INHIBITORS FOR TREATING AUTOIMMUNE DISEASES AND CHRONIC INFLAMMATION

The present invention relates to compounds of the general formula (I), and the pharmaceutically acceptable salts and solvates thereof, wherein Ar, Z and Y are as described herein and R1 is a group of the structure (formula (II)), wherein n is 0 or 1; R2 is H, deuterium or methyl; R3 is methyl, trilluoromethyl, ethyl, or taken with R2 together forms a cyclopropyl group, or R3 forms a methylene bridge to the carbon atom marked *, which are suitable for the treatment of autoimmune diseases and chronic inflammation.

IL17 AND IFN-GAMMA INHIBITION FOR THE TREATMENT OF AUTOIMMUNE INFLAMMATION

The present invention relates to compounds of the general formula (I), and the pharmaceutically acceptable salt or solvate thereof, as anti-inflammatory and immunomodulatory agents.