267639-76-9

Basic information

• Product Name: Romiplostim
• Synonyms: Romiplostim;romiplostim(Nplate)
• CAS NO: 267639-76-9
• Molecular Formula: C15H14N2O
• Molecular Weight: 238.28446
• Mol File: 267639-76-9.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Romiplostim(CAS DataBase Reference)
• NIST Chemistry Reference: Romiplostim(267639-76-9)
• EPA Substance Registry System: Romiplostim(267639-76-9)

Safety Data

• Hazardous Substances Data: 267639-76-9(Hazardous Substances Data)

Usage

Description

Romiplostim, also known as Nplate, is a recombinant fusion protein engineered as a peptibody that serves as a TPO receptor agonist. It is designed to contain two identical single-chain subunits, each consisting of a TPO-binding domain linked to the C-terminus of a human IgG1 Fc domain, which increases the half-life of the protein. Romiplostim is used for the treatment of thrombocytopenia in patients with ITP, an autoimmune blood disorder characterized by autoantibody-mediated platelet destruction and impaired platelet production.

Uses

Used in Pharmaceutical Industry:
Romiplostim is used as a TPO receptor agonist for the treatment of thrombocytopenia in patients with ITP. By binding to and activating the TPO receptor, it helps remediate the platelet production contribution of ITP and mitigates the risks associated with the first-generation predecessor, recombinant megakaryocyte growth and development factor (MGDF).
Additionally, romiplostim is used to avoid the side effects associated with generalized immunosuppressive agents previously employed for the treatment of ITP and may prevent splenectomy, another common treatment option.

Clinical Use

Fc-peptide fusion protein: Treatment of chronic immune (idiopathic) thrombocytopenic purpura (ITP)

Drug interactions

Potentially hazardous interactions with other drugs None known

Metabolism

Mainly renal clearance.