26782-74-1

Basic information

• Product Name: (S)-2-CHLORO-3-METHYLBUTYRIC ACID
• Synonyms: (S)-2-CHLOROISOVALERIC ACID;(S)-(-)-2-CHLORO 3-METHYLBUTANOIC ACID;(S)-(-)-2-CHLORO-3-METHYLBUTYRIC ACID;(S)-2-CHLORO-3-METHYLBUTYRIC ACID;(S)-ALPHA-CHLOROISOVALERIC ACID;(s)-α-chloroisovaleric acid;(S)-2-CHLORO-3-METHYLBUTYRIC ACID GC 97+%;(S)-2-CHLORO-3-METHY
• CAS NO: 26782-74-1
• Molecular Formula: C₅H₉ClO₂
• Molecular Weight: 136.58
• Product Categories: chiral;Building Blocks for Liquid Crystals;Carboxylic Acids (Chiral);Chiral Building Blocks;Chiral Compounds (Building Blocks for Liquid Crystals);Functional Materials;Synthetic Organic Chemistry
• Mol File: 26782-74-1.mol
• Article Data: 24

Chemical Properties

• Boiling Point: 109 °C / 16mmHg
• Flash Point: 81.004 °C
• Appearance: /
• Density: 1.144 g/mL at 20 °C(lit.)
• Vapor Pressure: 0.0768mmHg at 25°C
• Refractive Index: n20/D 1.443
• Storage Temp.: 2-8°C
• PKA: 3.02±0.14(Predicted)
• CAS DataBase Reference: (S)-2-CHLORO-3-METHYLBUTYRIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-CHLORO-3-METHYLBUTYRIC ACID(26782-74-1)
• EPA Substance Registry System: (S)-2-CHLORO-3-METHYLBUTYRIC ACID(26782-74-1)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 3265 8/PG 3
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 26782-74-1(Hazardous Substances Data)

Usage

General Description

(S)-2-Chloro-3-methylbutyric acid, also known as lactic acid, is a chemical compound that belongs to the family of carboxylic acids. It is a chiral compound, meaning it has two enantiomers, (R)- and (S)-. (S)-2-Chloro-3-methylbutyric acid has a molecular formula of C5H9ClO2 and a molecular weight of 136.58 g/mol. It is a colorless liquid with a sweet, pungent odor and is soluble in water. (S)-2-CHLORO-3-METHYLBUTYRIC ACID is often used in the synthesis of pharmaceuticals and agrochemicals. It is also used as a reagent in organic chemical reactions and as a building block for the preparation of various compounds in the chemical industry.

InChI:InChI=1/C5H9ClO2/c1-3(2)4(6)5(7)8/h3-4H,1-2H3,(H,7,8)/t4-/m0/s1

Upstream product

• 72-18-4 L-valine 
• 640-68-6 D-Val-OH 
• 503-74-2 3-methylbutyric acid 
• 167937-28-2 1,2;5,6-di-O-(1-methylethylidene)-α-D-glucofuranosyl-2-chloro-3-methyl butanoate 
• 161661-13-8 1-<1,2;5,6-di-O-(1-methylethylidene)-α-D-glucofuranosyloxy>-1-trimethylsilyloxy-3-methyl-but-1-ene 
• 139193-62-7 1,2;5,6-di-O-(1-methylethylidene)-α-D-glucofuranosyl 3-methyl butanoate 

Downstream Products

• 1599459-86-5 (2'S)-5-bromo-2-(2'-chloro-3'-methylbutanamido)benzoic acid 
• 1599459-84-3 (2'S)-4-chloro-2-(2'-chloro-3'-methylbutanamido)benzoic acid 
• 1190832-58-6 C₁₁H₁₅ClN₂O 
• 137349-26-9 (1-phthalimido-2-methyl)propyl-5-phenyloxazole 
• 143238-72-6 2'-<6'-((2''S-2''-chloro-3''-methylbutanoyl)oxy)>naphthyl 4-decyloxybenzoate 
• 82378-47-0 (R)-2-isopropyloxirane 
• 21671-21-6 (S)-3-methyl-2-(phenylamino)butanoic acid 

Relevant articles and documents

Preparation of Sephadex Derivatives with Optically Active Groups and Column-chromatographic Application to the Resolution of Some Cobalt(III) Complexes

Optically active cation-exchangers were newly prepared as Sephadex derivatives derived from L-alanine, L-valine, L-aspartic acid, and L-threonine.They were applied to the column-chromatographic resolution of some cobalt(III) complexes, partial resolution being attained.

CRYSTALLINE FORMS OF A CD73 INHIBITOR

The present invention relates to crystalline forms of 5-[5-[2-isopropylcyclopropyl] -6-methyl-pyridazin-3-yl]-1H-pyrimidine-2,4-dione, and pharmaceutical compositions comprising them, which inhibit the activity of CD73 and are useful for treating cancer.

CD73 INHIBITORS

The present invention provides 5-[5]-[2-cycloa Ikyl ]-6-pyridazin-3-yl ]- IH-pyrimidine-2,4-dione compounds, or pharmaceutically acceptable salts thereof, that inhibit the activity of CD73 and are useful in treating cancer. (Formula (I))

Di(1-naphthyl) methanol ester of carboxylic acids for absolute stereochemical determination

The absolute stereochemistry of chiral carboxylic acids is determined as a di(1-naphthyl)methanol ester derivative. Computational scoring of conformations favoring either P or M helicity of the naphthyl groups, capable of exciton-coupled circular dichroic coupling, leads to a predicted stereochemistry for the derivatized carboxylic acids.