267888-94-8

Basic information

• Product Name: [2-(4-Benzyloxy-phenyl)-ethyl]-((S)-1-phenyl-ethyl)-amine
• CAS NO: 267888-94-8
• Molecular Weight: 331.458
• Mol File: 267888-94-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [2-(4-Benzyloxy-phenyl)-ethyl]-((S)-1-phenyl-ethyl)-amine(CAS DataBase Reference)
• NIST Chemistry Reference: [2-(4-Benzyloxy-phenyl)-ethyl]-((S)-1-phenyl-ethyl)-amine(267888-94-8)
• EPA Substance Registry System: [2-(4-Benzyloxy-phenyl)-ethyl]-((S)-1-phenyl-ethyl)-amine(267888-94-8)

Safety Data

• Hazardous Substances Data: 267888-94-8(Hazardous Substances Data)

Upstream product

• 100-39-0 benzyl bromide 
• 56441-69-1 2-<4-(phenylmethoxy)phenyl>acetic acid ethyl ester 
• 17138-28-2 (4-hydroxy-phenyl)-acetic acid ethyl ester 
• 6547-53-1 2-[4-(benzyloxy)benzyl]acetic acid 

Downstream Products

• 267889-01-0 (2S,3S,4R)-1-{2-[4-(tert-Butyl-diphenyl-silanyloxy)-phenyl]-ethyl}-4-hydroxy-5-[2-oxo-octadec-(E)-ylidene]-2-propyl-pyrrolidine-3-carboxylic acid methyl ester 
• 267888-99-3 (2S,3R,4R)-1-{2-[4-(tert-Butyl-diphenyl-silanyloxy)-phenyl]-ethyl}-4-hydroxy-2-propyl-5-thioxo-pyrrolidine-3-carboxylic acid methyl ester 
• 267889-00-9 (2S,3S,4R)-1-{2-[4-(tert-Butyl-diphenyl-silanyloxy)-phenyl]-ethyl}-4-hydroxy-2-propyl-5-thioxo-pyrrolidine-3-carboxylic acid methyl ester 
• 267888-96-0 (2R,3R)-2-{(S)-1-[[2-(4-Benzyloxy-phenyl)-ethyl]-((S)-1-phenyl-ethyl)-amino]-butyl}-3-hydroxy-succinic acid 4-ethyl ester 1-methyl ester 
• 267888-98-2 4-(tert-butyl-dimethyl-silanyloxy)-1-{2-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-ethyl}-2-propyl-5-thioxo-pyrrolidine-3-carboxylic acid methyl ester 
• 267888-97-1 (2S,3R,4R)-4-Hydroxy-1-[2-(4-hydroxy-phenyl)-ethyl]-5-oxo-2-propyl-pyrrolidine-3-carboxylic acid methyl ester 
• 155944-28-8 (2S,3S,4R)-plakoridine A 
• 267888-95-9 (S)-3-[[2-(4-Benzyloxy-phenyl)-ethyl]-((S)-1-phenyl-ethyl)-amino]-hexanoic acid methyl ester 

Relevant articles and documents

Total synthesis of (2S,3s,4R)-plakoridine A

The β-amino ester 6 is synthesized via the diastereoselective Michael addition of the lithium amide derived from amine 5 to methyl (E)-2-hexenoate. This ester is converted to the pyrrolidinone 8 via an aldol condensation/deprotection/cyclization. Transformation of the lactam 8 into thiolactam 11 followed by Eschenmoser sulfide contraction provides (2S,3S,4R)-plakoridine A. (C) 2000 Elsevier Science Ltd.