26815-04-3

Basic information

• Product Name: 4-[2-(1-Piperidinyl)ethoxy]benzaldehyde
• Synonyms: ASISCHEM C56804;4-(2-piperidine-1-ethyloxy)benzaldehyde;4-(2-PIPERIDINYLETHOXY) BENZALDEHYDE;4-[2-(1-PIPERIDINYL) ETHOXY] BENZALDEHYDE;AKOS BC-2071;PIPEB;4-[2-(N-Piperidyl)]Ethoxybenzaldehyde98%;4-(2-Piperidin-1-Yl-Ethoxy)Benzaldehyde
• CAS NO: 26815-04-3
• Molecular Formula: C₁₄H₁₉NO₂
• Molecular Weight: 233.31
• Mol File: 26815-04-3.mol
• Article Data: 31

Chemical Properties

• Boiling Point: 378.5°C at 760 mmHg
• Flash Point: 182.7°C
• Appearance: /
• Density: 1.084g/cm³
• Vapor Pressure: 6.25E-06mmHg at 25°C
• Refractive Index: 1.554
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-[2-(1-Piperidinyl)ethoxy]benzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[2-(1-Piperidinyl)ethoxy]benzaldehyde(26815-04-3)
• EPA Substance Registry System: 4-[2-(1-Piperidinyl)ethoxy]benzaldehyde(26815-04-3)

Safety Data

• Hazardous Substances Data: 26815-04-3(Hazardous Substances Data)

Usage

General Description

4-[2-(1-Piperidinyl)ethoxy]benzaldehyde is a chemical compound with the molecular formula C14H19NO2. Its exact mass is 231.1422 g/mol and its monoisotopic mass is 231.141907 g/mol. The polarity of this compound is characterized by a fairly even distribution of electrons, hence an almost uniform negative and positive charge throughout the molecule. 4-[2-(1-Piperidinyl)ethoxy]benzaldehyde is commonly used in the field of organic synthesis, having convenient properties for the production of a variety of organic compounds. Details about its toxicity or usage restrictions are not readily available, suggesting it's mostly employed in controlled industrial or laboratory environments.

InChI:InChI=1/C14H19NO2/c16-12-13-4-6-14(7-5-13)17-11-10-15-8-2-1-3-9-15/h4-7,12H,1-3,8-11H2

Upstream product

• 2008-75-5 N-chloroethylpiperidine hydrochloride 
• 123-08-0 4-hydroxy-benzaldehyde 
• 104-88-1 4-chlorobenzaldehyde 
• 110-89-4 piperidine 
• 54373-15-8 4-(2-chloroethoxy)benzaldehyde 
• 52191-15-8 4-(2-bromoethyloxy)benzaldehyde 
• 3040-44-6 1-piperidinoethanol 
• 408538-22-7 N-hydroxyethylpiperidine 
• 584-08-7 potassium carbonate 
• 223251-13-6 [4-[2-(1-piperidinyl)ethoxy]phenyl]methanol 
• 1932-03-2 2-(piperidin-4-yl)ethyl chloride 

Downstream Products

• 104396-95-4 [2-methyl-4-(2,6,6-trimethyl-cyclohex-1-enyl)-butyl]-[4-(2-piperidino-ethoxy)-benzyl]-amine 
• 223251-13-6 [4-[2-(1-piperidinyl)ethoxy]phenyl]methanol 
• 1172118-49-8 1-(2-(4-(4,5-diphenyl-1H-imidazol-2-yl)phenoxy)ethyl)piperidine 
• 1416896-86-0 (2E,5E)-2,5-bis(4-(2-(piperidin-1-yl)ethoxy)benzylidene)cyclopentanone 
• 1416896-87-1 C₃₄H₄₄N₂O₃ 
• 123-08-0 4-hydroxy-benzaldehyde 

Relevant articles and documents

Evaluation of 2-(piperidine-1-yl)-ethyl (PIP) as a protecting group for phenols: Stability to ortho-lithiation conditions and boiling concentrated hydrobromic acid, orthogonality with most common protecting group classes, and deprotection via Cope elimination or by mild Lewis acids

A new protecting group, 2-(piperidine-1-yl)-ethyl (PIP), was evaluated as a protecting group for phenols. The PIP group was stable to ortho-lithiation conditions and refluxing with concentrated hydrobromic acid. Deprotection was accomplished by two routes, oxidation to N-oxides followed by Cope elimination (CE) and subsequent hydrolysis or ozonolysis of the vinyl ether or one-step deprotection by BBr3?Me2S. The PIP group is orthogonal to the O-benzyl, O-acetyl, O-t-butyldiphenylsilyl, O-methyl, O-p-methoxybenzyl, O-allyl, O-tetrahydropyranyl and N-t-butoxy carbonyl groups. The CE step was systematically studied and was found to give higher yields when the reaction was performed in the presence of silylating agents.

TOLL-LIKE RECEPTOR SIGNALING INHIBITORS

Di- and triaryl-substituted heteroaromatic compounds have Toll-like receptor inhibitory activity, including at TLR2, TLR4, TLR7, and/or TLR9. Compounds and compositions have applications in the treatment of diseases and conditions mediated by Toll-like receptors and related receptors, such as bacterial sepsis, autoimmune disease, lupus erythematosus, ischemia-reperfusion injury, stroke, metabolic disease, obesity-related metabolic inflammation, gout, and cancer.

Development of chalcone-O-alkylamine derivatives as multifunctional agents against Alzheimer's disease

A series of novel chalcone-O-alkylamine derivatives were designed, synthesized and evaluated as multifunctional anti-Alzheimer's disease agents. Based on the experimental results, compound 23c exhibited good inhibitory potency on both acetylcholinesterase