26833-85-2 Usage
Description
Harringtonine, a natural alkaloid, is known for its significant antitumor activities and its ability to inhibit protein synthesis at low micromolar concentrations. It has been studied extensively for its effects on ribosomes and its potential applications in cancer treatment. The full structure of harringtonine has been established through the analysis of its hydrolysis products. It is a white solid and has drawn interest in the field of oncology, particularly for its specific anti-leukemia properties.
Uses
Used in Oncology:
Harringtonine is used as a specific anti-leukemia drug for its significant antitumor activities. It is particularly effective against chronic myelogenous leukemia, where it has shown promising results in mitigating the disease.
Used in Cancer Treatment:
Harringtonine is used as a natural product with significant antitumor activities in cancer treatment. Its ability to inhibit protein synthesis and immobilize ribosomes makes it a valuable compound in the development of novel therapeutic strategies against various types of cancer.
Used in Translational Research:
Harringtonine is used as a tool to capture ribosome-protected mRNA fragments for evaluating translation. Its ability to immobilize initiating ribosomes can provide valuable insights into the process of translation and help researchers better understand the molecular mechanisms underlying various diseases, including cancer.
References
Mikolajczak, Powell, Smith, Tetrahedron, 28, 1995 (1972)
Kelly, McKenna, Christenson, Tetrahedron Lett., 35m (1973)
Check Digit Verification of cas no
The CAS Registry Mumber 26833-85-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,6,8,3 and 3 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 26833-85:
(7*2)+(6*6)+(5*8)+(4*3)+(3*3)+(2*8)+(1*5)=132
132 % 10 = 2
So 26833-85-2 is a valid CAS Registry Number.
InChI:InChI=1/C28H37NO9/c1-26(2,32)8-9-28(33,15-22(30)35-4)25(31)38-24-21(34-3)14-27-7-5-10-29(27)11-6-17-12-19-20(37-16-36-19)13-18(17)23(24)27/h12-14,23-24,32-33H,5-11,15-16H2,1-4H3/t23-,24-,27+,28-/m1/s1
26833-85-2Relevant articles and documents
Synthesis method and intermediate of ester derivative of (-)-cephalotaxine
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Paragraph 0213-0215, (2019/12/29)
The invention discloses a synthesis method and an intermediate of an ester derivative of (-)-cephalotaxine. The synthesis method is characterized in that a compound A and a compound 4 undergoes a condensation reaction shown in the description in a solvent under the action of a condensing agent in order to obtain a compound I. The synthetic method utilizes an esterification reaction of a racemic epoxy branched-chain compound and the (-)-cephalotaxine to highly selectively obtain the chiral compound close to a single configuration, so the method has the advantages of simple and mild synthesis route, and easiness in industrialization.
Preparation of harringtonine from cephalotaxine
Kelly,McNutt Jr.,Montury,et al.
, p. 63 - 66 (2007/10/10)
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