268544-50-9Relevant articles and documents
A method for producing the active MICA environmental protection (by machine translation)
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Paragraph 0040, (2018/04/01)
A active MICA environment-friendly production method, comprises the following steps: oximation, alkylation, chlorinated, ring, process for preparing the intermediate. The invention realizes the recycled, thereby reducing the cost, reduces the amount of waste and waste water; will be S1 in the recrystallization of the sodium acetate as by-product, for S4 in the ring, reducing the waste water and its salt content; in S2 in, now process generally utilizes a potassium carbonate to provide alkaline environment, general in the consumption of 2 more than one equivalent, shortcomings are as follows: a, in the salt in the reaction process too big stirring strenous, b, post-processing needs a large amount of water dissolved inorganic salt, form a large amount of high salt waste water, is changed into the organic base after the solid salt in the reaction process is greatly reduced, post-processing of organic base recycling, reducing the cost and amount of waste water; S3 using batch feeding mode, can be reduced under the same conversion rate, the amount of sulfonyl chloride; S5 recycling reaction generated by-product 2 - mercaptobenzothiazole, recycled in the synthesis of disulphide diphenyl thiazole. (by machine translation)
3-Phosphonium and 3-phosphoranylidenecephems
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, (2008/06/13)
This invention relates to novel 7-acylamino-3-vinylcephalosporanic acid derivatives of high antimicrobial activity, to processes for preparation thereof from novel intermediates, and to said intermediates of the formula: STR1 in which RA is a group of the formula: STR2 wherein R1 is amino-substituted-heterocyclic group which may have halogen, protected amino-substituted-heterocyclic group which may have halogen, or a group of the formula: STR3 wherein R3 is lower alkyl, R8 is aryl, A is lower alkylene which may have a substituent selected from the group consisting of amino, a protected amino group, hydroxy, oxo and a group of the formula: wherein R4 is hydrogen, cyclo(lower)alkenyl, lower alkynyl, lower alkenyl, lower alkenyl substituted by carboxy or a protected carboxy group, lower alkyl, or lower alkyl substituted by one or more substituent(s) selected from carboxy, a protected carboxy group, amino, a protected amino group, cyano, phosphono, a protected phosphono group and a heterocyclic group which may have suitable substituent(s), Ra is a protected amino group, Rb is a protected carboxy group, RB is a group of the formula: wherein R7 is aryl, and X2 and X3 are each halogen, and R2 is carboxy or a protected carboxy group, provided that, when RA is a group of the formula: R8 --CH=N--, wherein R8 is as defined above, then RB is a group of the formula: wherein R7 and X3 are each as defined above, or a salt thereof.
