268544-89-4

Basic information

• Product Name: 1H-Pyrazole-3,4-dicarboxylic acid, 1-(4-chlorophenyl)-5-methyl-, 4-methyl ester
• CAS NO: 268544-89-4
• Molecular Formula: C13H11ClN2O4
• Molecular Weight: 294.694
• Mol File: 268544-89-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1H-Pyrazole-3,4-dicarboxylic acid, 1-(4-chlorophenyl)-5-methyl-, 4-methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrazole-3,4-dicarboxylic acid, 1-(4-chlorophenyl)-5-methyl-, 4-methyl ester(268544-89-4)
• EPA Substance Registry System: 1H-Pyrazole-3,4-dicarboxylic acid, 1-(4-chlorophenyl)-5-methyl-, 4-methyl ester(268544-89-4)

Safety Data

• Hazardous Substances Data: 268544-89-4(Hazardous Substances Data)

Upstream product

• 127107-00-0 ethyl 2-amino-3-methoxycarbonyl-4-oxo-2-pentanoate 
• 1073-69-4 N-4-chlorophenylhydrazine 
• 471-47-6 oxamic acid 
• 1073-70-7 4-chlorophenylhydrazine hydrochloride 
• 105-45-3 acetoacetic acid methyl ester 
• 268544-84-9 ethyl 1-(4-chlorophenyl)-4-(methoxycarbonyl)-5-methyl-3-pyrazolecarboxylate 

Downstream Products

• 268544-99-6 methyl 3-cyclopropylcarboxamido-1-(4-chlorophenyl)-5-methyl-4-pyrazolecarboxylate 
• 268544-94-1 methyl 3-tert-butylcarboxamido-1-(4-chlorophenyl)-5-methyl-4-pyrazolecarboxylate 
• 1026591-00-3 3-chlorocarbonyl-1-(4-chloro-phenyl)-5-methyl-1H-pyrazole-4-carboxylic acid methyl ester 

Relevant articles and documents

Expeditious solid-phase synthesis of pyrazoledicarboxylic acid derivatives by functionalization of resin-bound cyanoformate

Esterification of the Wang resin 5 with the monoamide of oxalic acid (oxamic acid, 7) followed by dehydration of the amide function furnishes the resin-bound cyanoformate 9, which can be elaborated by zinc-catalyzed reaction with β-keto esters. The obtained enamino keto diesters 10a-d react with hydrazines affording, after removal from the solid support, fully substituted pyrazoledicarboxylic acids 12a-n. Optimization of the above sequence and the solid-phase synthesis of a small test-library of 1,5-disubstituted pyrazole-3,4-dicarboxylic acid derivatives are described. Wiley-VCH Verlag GmbH & Co. KGaA, 2005.