26873-85-8

Basic information

• Product Name: Polysucrose
• Synonyms: FICOLL;FICOLL 400;FICOLL-400(TM);FICOLL(R) 400;FICOLL(R) 400000;FICOLL(R) 400 REAGENT;FICOLL(R) PM 400;FICOLL(R)
• CAS NO: 26873-85-8
• Molecular Formula: C15H27ClO12
• Molecular Weight: 434.82068
• EINECS: 200-334-9
• Product Categories: Dextrins、Sugar & Carbohydrates;Cell Separation (Centrifugation) MediaResearch Essentials;Centrifugation MediaStem Cell Biology;Core Bioreagents;GradientsHematopoietic Stem Cell Biology;Hematology and Histology;Hematopoietic Stem Cell Isolation;Separation;Stem Cell Isolation;Carbohydrates;Carbohydrates A to;Carbohydrates D-FBiochemicals and Reagents;Polysaccharide;Cell Culture;Cell SeparationHematology and Histology;Reagents and Supplements;Cell Separation (Centrifugation) MediaStem Cell Biology
• Mol File: 26873-85-8.mol
• Article Data: 0

Chemical Properties

• Appearance: White/lyophilized powder
• Storage Temp.: 2-8°C
• Solubility: H2O: 0.1 g/mL, slightly turbid, colorless
• Water Solubility: Soluble in water.
• CAS DataBase Reference: Polysucrose(CAS DataBase Reference)
• NIST Chemistry Reference: Polysucrose(26873-85-8)
• EPA Substance Registry System: Polysucrose(26873-85-8)

Safety Data

• Hazard Codes: Xi
• Safety Statements: 26-36
• WGK Germany: 3
• F: 3
• TSCA: Yes
• Hazardous Substances Data: 26873-85-8(Hazardous Substances Data)

Usage

Description

Polysucrose, also known as Ficoll, is a high molecular weight polymer formed by the copolymerization of sucrose with epichlorohydrin. It is a completely non-ionic, highly branched, and hydrophilic substance with a pH range of 7.0-8.0. Due to its unique properties, it is widely used in various applications, particularly in the field of biotechnology and pharmaceuticals.

Uses

Used in Biotechnology and Pharmaceutical Applications:
Polysucrose is used as a density gradient medium for the separation and isolation of eukaryotic cells, organelles, and bacterial cells. It helps in establishing density gradients up to 1.2 g/ml, which is crucial for cell separation and organelle isolation processes.
Used in the Purification of Human Motile Spermatozoa:
In a study, Polysucrose has been employed to develop a new method for the purification of human motile spermatozoa, which is essential for assisted reproductive technologies and fertility research.
Used in Cancer Research:
Polysucrose has been utilized in a study that investigated the antiproliferative and antitumor activities of D-reverse peptides. This application highlights its potential role in the development of novel cancer therapies and understanding the underlying mechanisms of cancer cell growth inhibition.
Used in the Separation Medium Ficoll-Paque:
Ficoll, a hydrophilic neutral highly branched polysaccharide, is part of the separation medium called Ficoll-Paque. It is used to separate blood component cells and organelles, which is vital for various diagnostic and research purposes.