269075-68-5

Basic information

• Product Name: 2-[2-(2',4'-Difluorobiphenyl-4-yl)-2-oxoethoxy]-3-methoxybenzonitrile
• Synonyms: 2-[2-(2',4'-Difluorobiphenyl-4-yl)-2-oxoethoxy]-3-methoxybenzonitrile
• CAS NO: 269075-68-5
• Molecular Weight: 379.363
• Mol File: 269075-68-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-[2-(2',4'-Difluorobiphenyl-4-yl)-2-oxoethoxy]-3-methoxybenzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[2-(2',4'-Difluorobiphenyl-4-yl)-2-oxoethoxy]-3-methoxybenzonitrile(269075-68-5)
• EPA Substance Registry System: 2-[2-(2',4'-Difluorobiphenyl-4-yl)-2-oxoethoxy]-3-methoxybenzonitrile(269075-68-5)

Safety Data

• Hazardous Substances Data: 269075-68-5(Hazardous Substances Data)

Upstream product

• 148-53-8 3-methoxy-2-hydroxybenzaldehyde 
• 6812-16-4 2-Hydroxy-3-methoxybenzonitrile 
• 134563-11-4 2-Bromo-1-(2',4'-difluorobiphenyl-4-yl)ethan-1-one 

Relevant articles and documents

Synthesis and analgesic activity of some 1-benzofurans, 1-benzothiophenes and indoles

3-Unsubstituted 1-benzofurans 1e and 1f, 3-methyl-1-benzofurans 1a-1d, and 3-amino-1-benzofurans 2a-21, as well as 3-amino-1-benzothiophenes 3a, 3b and 3-aminoindoles 4a-4f, 11a, and 11b were prepared and tested as analgesics. The 3-amino-1-benzofurans 2 were prepared from the corresponding 2-hydroxybenzonitriles 5 and phenacyl bromides 6 via intermediates 7. Similar treatment of 2-sulfanylbenzonitrile (8) provided 3-amino-1-benzothiophenes 3. Appropriately substituted 2-aminobenzonitriles 9 then provided N-substituted 3-aminoindoles 4. 1-(Ethoxycarbonyl)indoles 4e and 4f were successfully deprotected giving indoles 11a and 11b, respectively.