26939-01-5

Basic information

• Product Name: (5-chloro-2-methoxyphenyl)acetic acid methyl ester
• Synonyms: (5-chloro-2-methoxyphenyl)acetic acid methyl ester
• CAS NO: 26939-01-5
• Molecular Formula: C₁₀H₁₁ClO₃
• Molecular Weight: 214.64554
• Mol File: 26939-01-5.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 275.2°Cat760mmHg
• Flash Point: 110°C
• Appearance: /
• Density: 1.204g/cm³
• Vapor Pressure: 0.005mmHg at 25°C
• Refractive Index: 1.516
• CAS DataBase Reference: (5-chloro-2-methoxyphenyl)acetic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (5-chloro-2-methoxyphenyl)acetic acid methyl ester(26939-01-5)
• EPA Substance Registry System: (5-chloro-2-methoxyphenyl)acetic acid methyl ester(26939-01-5)

Safety Data

• Hazardous Substances Data: 26939-01-5(Hazardous Substances Data)

Usage

General Description

"(5-chloro-2-methoxyphenyl)acetic acid methyl ester" is a chemical compound that is derived from the esterification of (5-chloro-2-methoxyphenyl)acetic acid with methanol. It is a colorless, liquid substance with a molecular formula C10H11ClO3. (5-chloro-2-methoxyphenyl)acetic acid methyl ester has various potential applications in the field of organic synthesis and pharmaceutical chemistry, where it can be used as a building block for the synthesis of more complex molecules or as a precursor in drug development. Additionally, it may have potential use as an intermediate in the production of agrochemicals and other specialty chemicals. However, like all chemical compounds, it should be handled and used with care, following appropriate safety guidelines and regulations.

InChI:InChI=1/C10H11ClO3/c1-13-9-4-3-8(11)5-7(9)6-10(12)14-2/h3-5H,6H2,1-2H3

Upstream product

• 124-41-4 sodium methylate 
• 93-25-4 2-methoxyphenylacetic acid 
• 7569-62-2 (5-chloro-2-methoxy-phenyl)-acetic acid 
• 584-08-7 potassium carbonate 
• 77-78-1 dimethyl sulfate 
• 67-56-1 methanol 
• 7569-63-3 (5-chloro-2-methoxyphenyl)acetyl chloride 

Downstream Products

• 183720-28-7 3-(5-Chloro-2-methoxyphenyl)-3-fluoro-1,3-dihydro-6-(trifluoromethyl)-2H-indol-2-one 
• 385764-29-4 (+)-3-(5-chloro-2-methoxyphenyl)-1,3-dihydro-6-(trifluoromethyl)-2H-indol-2-one 
• 183720-52-7 methyl 2-(5-chloro-2-methoxyphenyl)-2-(2-nitro-4-(trifluoromethyl)phenyl)acetate 
• 7569-62-2 (5-chloro-2-methoxy-phenyl)-acetic acid 
• 206194-02-7 (S)-(-)-5-Chloro-2-methoxy-α-fluoro-α-[2-nitro-4-(trifluoromethyl)phenyl]benzeneacetic acid 
• 206194-04-9 (R)-(+)-5-Chloro-2-methoxy-α-fluoro-α-[2-nitro-4-(trifluoromethyl)phenyl]benzeneacetic acid 
• 187523-36-0 (-)-BMS-204352 
• 187523-35-9 (S)-(+)-3-(5-chloro-2-methoxyphenyl)-3-fluoro-1,3-dihydro-6-(trifluoromethyl)-2H-indol-2-one 
• 206194-00-5 5-chloro-α-fluoro-2-methoxy-α-[2-nitro-4-(trifluoromethyl)-phenyl]benzeneacetic acid,methyl ester 

Relevant articles and documents

PREPARATION OF 3-FLUORO OXINDOLE DERIVATIVES

The present invention relates to novel itermediates of formula (1) wherein the wavy bond ( SIMILAR SIMILAR ) represents the racemate, the (R)-enantiomer or the (S)-enantiomer; and R is hydrogen, a carboxyl-protecting group or a cation of an addition salt;

The synthesis and characterization of BMS-204352 (MaxiPost) and related 3-fluorooxindoles as openers of maxi-K potassium channels

3-Aryl-3-fluorooxindoles can be efficiently synthesized in two steps by the addition of an aryl Grignard to an isatin, followed by treatment with DAST. Oxindole 1 (BMS-204352; MaxiPost) can be isolated using chiral HPLC or prepared by employing chiral res

3-SUBSTITUTED OXINDOLE DERIVATIVES AS POTASSIUM CHANNEL MODULATORS

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