269396-71-6 Usage
General Description
Boc-(R)-3-amino-4-(4-iodo-phenyl)-butyric acid is a chemical compound that contains a Boc (tert-butoxycarbonyl) protecting group, as well as an amino acid backbone with a 3-amino-4-(4-iodo-phenyl)-butyric acid side chain. Boc-(R)-3-amino-4-(4-iodo-phenyl)-butyric acid is commonly used in organic synthesis and peptide chemistry as a building block for the production of complex peptide structures. The 4-iodo-phenyl group provides opportunities for further modification and cross-coupling reactions, making it a valuable tool in the construction of biologically active peptides and pharmaceuticals. Additionally, the presence of the Boc protecting group facilitates the selective deprotection of the amine group, allowing for controlled and precise manipulation of the molecule in subsequent synthetic steps.
Check Digit Verification of cas no
The CAS Registry Mumber 269396-71-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,6,9,3,9 and 6 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 269396-71:
(8*2)+(7*6)+(6*9)+(5*3)+(4*9)+(3*6)+(2*7)+(1*1)=196
196 % 10 = 6
So 269396-71-6 is a valid CAS Registry Number.
InChI:InChI=1/C15H20INO4/c1-15(2,3)21-14(20)17-12(9-13(18)19)8-10-4-6-11(16)7-5-10/h4-7,12H,8-9H2,1-3H3,(H,17,20)(H,18,19)/t12-/m1/s1
269396-71-6Relevant articles and documents
Discovery of potent and selective β-homophenylalanine based dipeptidyl peptidase IV inhibitors
Xu, Jinyou,Ok, Hyun O.,Gonzalez, Edward J.,Colwell Jr., Lawrence F.,Habulihaz, Bahanu,He, Huaibing,Leiting, Barbara,Lyons, Kathryn A.,Marsilio, Frank,Patel, Reshma A.,Wu, Joseph K.,Thornberry, Nancy A.,Weber, Ann E.,Parmee, Emma R.
, p. 4759 - 4762 (2007/10/03)
Modification of in-house screening lead β-aminoacyl proline 8 gave an equipotent thiazolidide 9. Extensive SAR studies on the phenyl ring of 9 led to the discovery of a novel series of potent and selective DP-IV inhibitors. Introduction of a fluorine at the 2-position proved to be crucial for the potency of this series. The 2,5-difluoro (22q) and 2,4,5-trifluoro (22t) analogues were potent inhibitors of DP-IV (IC50 = 270, 119 nM, respectively).
