269396-77-2 Usage
General Description
Boc-(R)-3-Amino-4-(2-trifluoromethyl-phenyl)-butyric acid is a chemical compound that is commonly used in pharmaceutical research and development. It belongs to the class of amino acids and is a derivative of butyric acid, containing an additional amino group. The compound is often used as a building block in the synthesis of peptide drugs and has potential applications in the treatment of various medical conditions. Its specific structure, with a Boc-protecting group and a trifluoromethyl-phenyl functional group, makes it valuable for creating novel drug candidates with improved properties and bioavailability. The compound's chirality, as it contains the (R)-configuration, may also contribute to its unique pharmacological activity. Overall, Boc-(R)-3-Amino-4-(2-trifluoromethyl-phenyl)-butyric acid is an important chemical used in drug discovery and development with promising therapeutic potential.
Check Digit Verification of cas no
The CAS Registry Mumber 269396-77-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,6,9,3,9 and 6 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 269396-77:
(8*2)+(7*6)+(6*9)+(5*3)+(4*9)+(3*6)+(2*7)+(1*7)=202
202 % 10 = 2
So 269396-77-2 is a valid CAS Registry Number.
InChI:InChI=1/C16H20F3NO4/c1-15(2,3)24-14(23)20-11(9-13(21)22)8-10-6-4-5-7-12(10)16(17,18)19/h4-7,11H,8-9H2,1-3H3,(H,20,23)(H,21,22)/t11-/m1/s1
269396-77-2Relevant articles and documents
Discovery of potent and selective β-homophenylalanine based dipeptidyl peptidase IV inhibitors
Xu, Jinyou,Ok, Hyun O.,Gonzalez, Edward J.,Colwell Jr., Lawrence F.,Habulihaz, Bahanu,He, Huaibing,Leiting, Barbara,Lyons, Kathryn A.,Marsilio, Frank,Patel, Reshma A.,Wu, Joseph K.,Thornberry, Nancy A.,Weber, Ann E.,Parmee, Emma R.
, p. 4759 - 4762 (2007/10/03)
Modification of in-house screening lead β-aminoacyl proline 8 gave an equipotent thiazolidide 9. Extensive SAR studies on the phenyl ring of 9 led to the discovery of a novel series of potent and selective DP-IV inhibitors. Introduction of a fluorine at the 2-position proved to be crucial for the potency of this series. The 2,5-difluoro (22q) and 2,4,5-trifluoro (22t) analogues were potent inhibitors of DP-IV (IC50 = 270, 119 nM, respectively).
