269410-22-2

Basic information

• Product Name: 2-METHOXY-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENOL
• Synonyms: 4-HYDROXY-3-METHOXYPHENYLBORONIC ACID, PINACOL CYCLIC ESTER;4-HYDROXY-3-METHOXYPHENYLBORONIC ACID PINACOL ESTER;2-METHOXY-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENOL;2-Methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol,min.97%;2-METHOXY-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENOL, MIN. 97%;4-Hydroxy-3-methoxyphenylboronic acid, pinacol cyclic ester, 2-Methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol;2-Methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol,97%;2-Methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol4-Hydroxy-3-methoxyphenylboronic acid pinacol ester
• CAS NO: 269410-22-2
• Molecular Formula: C₁₃H₁₉BO₄
• Molecular Weight: 250.1
• Product Categories: Boronic acids;organic or inorganic borate
• Mol File: 269410-22-2.mol
• Article Data: 5

Chemical Properties

• Melting Point: 105-109 °C(lit.)
• Boiling Point: 367.3 °C at 760 mmHg
• Flash Point: 176 °C
• Appearance: White to cream/Crystalline Powder
• Density: 1.11 g/cm³
• Vapor Pressure: 6.5E-06mmHg at 25°C
• Refractive Index: 1.512
• Storage Temp.: Refrigerator (+4°C)
• PKA: 9.66±0.35(Predicted)
• CAS DataBase Reference: 2-METHOXY-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHOXY-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENOL(269410-22-2)
• EPA Substance Registry System: 2-METHOXY-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENOL(269410-22-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 269410-22-2(Hazardous Substances Data)

Usage

Description

2-METHOXY-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENOL is a white to cream crystalline powder with unique chemical properties. It is a derivative of phenol, featuring a methoxy group at the 2nd position and a tetramethyl-1,3,2-dioxaborolan-2-yl group at the 4th position. 2-METHOXY-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENOL is known for its potential applications in various chemical and pharmaceutical processes due to its distinct structural features.

Uses

Used in Pharmaceutical Industry:
2-METHOXY-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENOL is used as a reactant for the synthesis of various pharmaceutical compounds. Its unique structure allows it to be a valuable building block in the development of new drugs with potential therapeutic applications.
Used in Chemical Synthesis:
In the field of chemical synthesis, 2-METHOXY-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENOL is used as a reactant in various organic reactions, such as the Suzuki-Miyaura cross-coupling reaction. This reaction is a widely used method for the formation of carbon-carbon bonds, which are essential in the synthesis of complex organic molecules.
Used in the Synthesis of Potential Neoplastic Agents:
2-METHOXY-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENOL is utilized in the preparation of ethylidenedihydroindolones, which are considered potential neoplastic agents. These compounds have shown promise in the development of new treatments for various types of cancer.
Used in the Synthesis of 5,6-Dihydropyrrolo[2,1-b]isoquinoline Derivatives:
2-METHOXY-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENOL is also used in the synthesis of 5,6-dihydropyrrolo[2,1-b]isoquinoline derivatives, which serve as valuable scaffolds for the preparation of lamellarin analogs. These analogs can be further modified through regioselective bromination and Suzuki cross-coupling reactions, leading to the development of new compounds with potential applications in various fields, including pharmaceuticals and materials science.

InChI:InChI=1/C13H19BO4/c1-12(2)13(3,4)18-14(17-12)9-6-7-10(15)11(8-9)16-5/h6-8,15H,1-5H3

Upstream product

• 54771-60-7 4-acetyl-2-methoxyphenyl acetate 
• 73183-34-3 bis(pinacol)diborane 
• 90-05-1 2-methoxy-phenol 
• 7368-78-7 4-bromoguaiacol 

Downstream Products

• 897360-45-1 2,4-diamino-6-(4-hydroxy-3-methoxyphenyl)pyrido[3,2-d]pyrimidine 
• 875639-79-5 2-[3-methoxy-4-(4-methoxy-benzyloxy)-phenyl]-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane 
• 1216771-80-0 4-(2-amino-5-(4-hydroxy-3-methoxyphenyl)pyridin-3-yl)benzamide 
• 1402465-97-7 methyl 1-(6-(4-hydroxy-3-methoxyphenyl)pyridin-3-yl)cyclopropanecarboxylate 

Relevant articles and documents

NOVEL COMPOUND AND PHARMACEUTICAL COMPOSITION COMPRISING SAME

The present disclosure relates to a novel compound and a pharmaceutical composition comprising the same. The compound according to the present disclosure has effects for activating autophagy, and thus can be valuably used for preventing or treating diseas

Para-Selective, Iridium-Catalyzed C-H Borylations of Sulfated Phenols, Benzyl Alcohols, and Anilines Directed by Ion-Pair Electrostatic Interactions

Para C-H borylations (CHB) of tetraalkylammonium sulfates and sulfamates have been achieved using bipyridine-ligated Ir boryl catalysts. Selectivities can be modulated by both the length of the alkyl groups in the tetraalkylammonium cations and the substituents on the bipyridine ligands. Ion pairing, where the alkyl groups of the cation shield the meta C-H bonds in the counteranions, is proposed to account for para selectivity. The 4,4′-dimethoxy-2,2′-bipyridine ligand gave superior selectivities.

POLYMERIZABLE COMPOUNDS AND THE USE THEREOF IN LIQUID-CRYSTAL DISPLAYS

The present invention relates to polymerizable compounds, to processes and intermediates for the preparation thereof, to liquid-crystal media comprising them, and to the use of the polymerizable compounds and liquid crystalline media for optical, electro-