26964-35-2

Basic information

• Product Name: 5,7-DIMETHOXYISOFLAVONE
• Synonyms: 5,7-DIMETHOXYISOFLAVONE;5,7-Methoxyisoflavone;5,7-Dimethoxy-3-phenyl-4H-1-benzopyran-4-one
• CAS NO: 26964-35-2
• Molecular Formula: C₁₇H₁₄O₄
• Molecular Weight: 282.29
• Product Categories: Iso-Flavones
• Mol File: 26964-35-2.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 476.6 °C at 760 mmHg
• Flash Point: 213.5 °C
• Appearance: /
• Density: 1.242 g/cm³
• Vapor Pressure: 3.01E-09mmHg at 25°C
• Refractive Index: 1.598
• CAS DataBase Reference: 5,7-DIMETHOXYISOFLAVONE(CAS DataBase Reference)
• NIST Chemistry Reference: 5,7-DIMETHOXYISOFLAVONE(26964-35-2)
• EPA Substance Registry System: 5,7-DIMETHOXYISOFLAVONE(26964-35-2)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• RIDADR: UN 2811 6.1 / PGIII
• Hazardous Substances Data: 26964-35-2(Hazardous Substances Data)

Usage

General Description

5,7-Dimethoxyisoflavone is a natural chemical compound belonging to the isoflavone class. It is found in various plants and has been studied for its potential health benefits. 5,7-Dimethoxyisoflavone has been shown to have anti-inflammatory and antioxidant properties, making it a potential candidate for the treatment of various inflammatory and oxidative stress-related conditions. Additionally, it has been investigated for its potential role in promoting bone health and preventing bone loss. Its ability to modulate estrogen receptor activity also makes it a potential candidate for hormone-related conditions. However, further research is needed to fully understand its potential therapeutic applications and mechanism of action.

InChI:InChI=1/C17H14O4/c1-19-12-8-14(20-2)16-15(9-12)21-10-13(17(16)18)11-6-4-3-5-7-11/h3-10H,1-2H3

Upstream product

• 39604-66-5 2-hydroxy-4,6-dimethoxyphenyl benzyl ketone 
• 109-94-4 formic acid ethyl ester 
• 727-71-9 2-phenyl-2',4',6'-trihydroxyacetophenone 
• 853925-96-9 5,7-dimethoxy-4-oxo-3-phenyl-4H-chromene-2-carboxylic acid ethyl ester 
• 15485-75-3 5,7-dihydroxy-4-oxo-3-phenyl-4H-chromene-2-carboxylic acid ethyl ester 
• 153488-88-1 3-allyloxycarbonyl-5,7-dimethoxychroman-4-one 
• 3076-54-8 phenyllead(IV) triacetate 
• 54107-66-3 5,7-dimethoxy-4-chromanone 
• 1775-97-9 flavokawain B 
• 90-24-4 2-hydroxy-4,6-dimethoxyacetophenone 
• 1036-72-2 5,7-dimethoxyflavone 
• 853925-97-0 5,7-dimethoxy-4-oxo-3-phenyl-4H-chromene-2-carboxylic acid 
• 101521-59-9 2-hydroxy-5,7-dimethoxy-3-phenyl-chroman-4-one 
• 153488-99-4 3-allyloxycarbonyl-5,7-dimethoxy-3-phenylchroman-4-one 

Downstream Products

• 4044-00-2 5,7-dihydroxyisoflavone 
• 19725-43-0 5-hydroxy-7-methoxy-3-phenyl-chromen-4-one 
• 26200-06-6 5,7-dimethoxyisoflavone 

Relevant articles and documents

Synthesis of isoflavones containing naturally occurring substitution pattern by oxidative rearrangement of respective flavanones using thallium(III) p-tosylate

Claisen condensation of substituted 2′-hydroxyacetophenones 1a-c with aromatic aldehydes affords respective substituted 2′-hydroxychalcones 2a-n which on base catalyzed cyclization in pyridine:methanol:water (1:1:1) give respective flavanones 3a-n. The oxidative rearrangement of flavanones with thallium(III) p-tosylate furnishes respective isoflavones 4a-n in overall 62-72% yields starting from 1. The present methodology has been successfully applied for the synthesis of naturally occurring isoflavones such as di-O-methyldaidzein 4a, cabruvin 4b, pseudobabtigenin methylether 4d, 5,7-dimethoxyisoflavone 4f, 5,7,4′-trimethoxyisoflavone 4g, derrustone 4i, 7,8,3′,4′- tetramethoxyisoflavone 41, purpuranin-A 4m and 7,8,3′,4′,5′- pentamethoxyisoflavone 4n and thus the first synthesis of 4n is reported.