269726-80-9 Usage
General Description
Boc-(R)-3-Amino-4-(2-cyano-phenyl)-butyric acid is a chemical compound with the molecular formula C16H20N2O4. It is an amino acid derivative with a Boc (tert-butoxycarbonyl) protecting group attached to the nitrogen atom. Boc-(R)-3-Amino-4-(2-cyano-phenyl)-butyric acid is commonly used in peptide synthesis and as a building block for potential drug candidates. Its structure consists of a 3-amino-4-(2-cyano-phenyl)-butyric acid backbone, making it a valuable intermediate for the production of various pharmaceuticals and bioactive compounds. Additionally, it has potential applications in the development of new materials and research into biological processes and pathways.
Check Digit Verification of cas no
The CAS Registry Mumber 269726-80-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,6,9,7,2 and 6 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 269726-80:
(8*2)+(7*6)+(6*9)+(5*7)+(4*2)+(3*6)+(2*8)+(1*0)=189
189 % 10 = 9
So 269726-80-9 is a valid CAS Registry Number.
InChI:InChI=1/C16H20N2O4/c1-16(2,3)22-15(21)18-13(9-14(19)20)8-11-6-4-5-7-12(11)10-17/h4-7,13H,8-9H2,1-3H3,(H,18,21)(H,19,20)/t13-/m1/s1
269726-80-9Relevant articles and documents
Discovery of potent and selective β-homophenylalanine based dipeptidyl peptidase IV inhibitors
Xu, Jinyou,Ok, Hyun O.,Gonzalez, Edward J.,Colwell Jr., Lawrence F.,Habulihaz, Bahanu,He, Huaibing,Leiting, Barbara,Lyons, Kathryn A.,Marsilio, Frank,Patel, Reshma A.,Wu, Joseph K.,Thornberry, Nancy A.,Weber, Ann E.,Parmee, Emma R.
, p. 4759 - 4762 (2007/10/03)
Modification of in-house screening lead β-aminoacyl proline 8 gave an equipotent thiazolidide 9. Extensive SAR studies on the phenyl ring of 9 led to the discovery of a novel series of potent and selective DP-IV inhibitors. Introduction of a fluorine at the 2-position proved to be crucial for the potency of this series. The 2,5-difluoro (22q) and 2,4,5-trifluoro (22t) analogues were potent inhibitors of DP-IV (IC50 = 270, 119 nM, respectively).
