2700-30-3

Basic information

• Product Name: N,N-DIISOPROPYLFORMAMIDE
• Synonyms: TIMTEC-BB SBB007703;N-FORMYLDIISOPROPYLAMINE;N,N-DIISOPROPYLFORMAMIDE;Formamide, N,N-bis(1-methylethyl)-;Formamide, N,N-diisopropyl-;DIISOPROPYLFORMAMIDE;N,N-bis(1-methylethyl)formamide;N,N-Diisopropylformamide,98%
• CAS NO: 2700-30-3
• Molecular Formula: C₇H₁₅NO
• Molecular Weight: 129.2
• EINECS: 220-284-1
• Product Categories: Aldehydes;Aliphatics;Amides;Carbonyl Compounds;Organic Building Blocks
• Mol File: 2700-30-3.mol
• Article Data: 41

Chemical Properties

• Melting Point: 10-11 °C(lit.)
• Boiling Point: 196 °C(lit.)
• Flash Point: 167 °F
• Appearance: /
• Density: 0.89 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.408mmHg at 25°C
• Refractive Index: n20/D 1.437(lit.)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform, Methanol (Slightly)
• PKA: -0.56±0.70(Predicted)
• Water Solubility: Slightly soluble in water.
• BRN: 1745406
• CAS DataBase Reference: N,N-DIISOPROPYLFORMAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-DIISOPROPYLFORMAMIDE(2700-30-3)
• EPA Substance Registry System: N,N-DIISOPROPYLFORMAMIDE(2700-30-3)

Safety Data

• Safety Statements: 23-24/25
• WGK Germany: 3
• RTECS: OO3500000
• Hazardous Substances Data: 2700-30-3(Hazardous Substances Data)

Usage

Description

N,N-Diisopropylformamide, also known as N,N-DIISOPROPYLFORMAMIDE, is a clear light brown liquid with unique chemical properties. It is a formamide derivative characterized by the presence of two isopropyl groups attached to the nitrogen atom. The chemical ionisation and electron ionisation mass spectroscopic data, retention indices, and NMR spectra of N,N-diisopropylformamide have been studied, providing insights into its structure and potential applications.

Uses

Used in Pharmaceutical Industry:
N,N-Diisopropylformamide is used as a catalyst for various chemical reactions in the pharmaceutical industry. Its ability to facilitate and enhance the rate of reactions makes it a valuable component in the synthesis of certain drugs and medicinal compounds.
Used in Chemical Synthesis:
In the field of chemical synthesis, N,N-Diisopropylformamide is used as a catalyst to improve the efficiency and selectivity of specific reactions. Its unique properties allow it to lower the activation energy required for a reaction to occur, thus increasing the overall yield and reducing the time needed for the process.
Used in Research and Development:
N,N-Diisopropylformamide is also utilized in research and development settings, where its chemical properties are explored for potential applications in various fields. The study of its mass spectroscopic data, retention indices, and NMR spectra contributes to the understanding of its structure and reactivity, which can lead to the discovery of new uses and applications.

Flammability and Explosibility

Notclassified

InChI:InChI=1/C7H15NO/c1-6(2)8(5-9)7(3)4/h5-7H,1-4H3

Upstream product

• 64-18-6 formic acid 
• 108-18-9 diisopropylamine 
• 3424-21-3 triisopropylamine 
• 102-82-9 tributyl-amine 
• 50-00-0 formaldehyd 
• 7087-68-5 N-ethyl-N,N-diisopropylamine 
• 67-56-1 methanol 
• 124-38-9 carbon dioxide 
• 50978-45-5 3-oxobenzo[d]isothiazole-2(3H)-carbaldehyde 1,1-dioxide 
• 67-66-3 chloroform 
• 75-09-2 dichloromethane 
• 201230-82-2 carbon monoxide 
• 17622-65-0 tert-Butylperoxymethyl-diisopropyl-amine 

Downstream Products

• 68714-10-3 (1-ethylpropyl)diisopropylamine 
• 91904-99-3 N,N-diisopropyl-N'-(phenylsulfonyl)formimidamide 
• 121290-02-6 (E)-3-Diisopropylamino-3-phenyl-2-trifluoromethanesulfonyl-propenal 
• 10342-97-9 N,N-diisopropylmethylamine 
• 764-93-2 1-decyne 
• 112-31-2 caprinaldehyde 
• 1860-39-5 5-methylhexanal 
• 2203-80-7 5-methylhex-1-yne 
• 1192-58-1 N-methylpyrrole aldehyde 
• 36929-60-9 3-formyl-1-methylpyrrole 
• 23373-78-6 1-tert-Butyl-2-formyl-pyrrol 
• 30186-46-0 1-(tert-butyl)-1H-pyrrole-3-carbaldehyde 
• 120777-22-2 1-phenyl-1H-pyrrole-3-carbaldehyde 
• 30186-39-1 N-phenylpyrrole-2-carbaldehyde 

Relevant articles and documents

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Additive-free selective methylation of secondary amines with formic acid over a Pd/In2O3 catalyst

Formic acid is used as the sole carbon and hydrogen source in the methylation of aromatic and aliphatic amines to methylamines. The reaction proceeds via a formylation/transfer hydrogenation pathway over a solid Pd/In2O3 catalyst without the need for any additive.

N-formylation of amines using phenylsilane and CO2 over ZnO catalyst under mild condition

Several research studies have been conducted on N-formylation of amines using phenylsilane and CO2. However, most of these studies involved tedious processes of catalyst preparation or complex procedures. In the present study, we describe the use of a simple and commercially available ZnO catalyst for selective N-formylation of amines under mild condition. High-yielding N-formylation products with good recyclability and wide substrate scope were obtained, which can promote fine chemical synthesis and CO2 capture.

Copper-Catalyzed Formylation of Amines by using Methanol as the C1 Source

Cu/TEMPO catalyst systems are known for the selective transformation of alcohols to aldehydes, as well as for the simultaneous coupling of alcohols and amines to imines under oxidative conditions. In this study, such a Cu/TEMPO catalyst system is found to catalyze the N-formylation of a variety of amines by initial oxidative activation of methanol as the carbonyl source via formaldehyde and formation of N,O-hemiacetals and oxidation of the latter under very mild conditions. A vast range of amines, including aromatic and aliphatic, primary and secondary, and linear and cyclic amines are formylated under these conditions with good to excellent yields. Moreover, paraformaldehyde can be used instead of methanol for the N-formylation.