27063-93-0

Basic information

• Product Name: 3-BROMO-2,4-DIMETHYLPYRIDINE
• Synonyms: 3-BROMO-2,4-DIMETHYLPYRIDINE;PYRIDINE, 3-BROMO-2,4-DIMETHYL;3-Bromo-2,4-Dimethylpiperidine;3-BroMo-2,4-lutidine
• CAS NO: 27063-93-0
• Molecular Formula: C7H8BrN
• Molecular Weight: 186.05
• Mol File: 27063-93-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 208.8°C at 760 mmHg
• Flash Point: 80.1°C
• Appearance: /
• Density: 1.415g/cm³
• Vapor Pressure: 0.303mmHg at 25°C
• Refractive Index: 1.547
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 4.25±0.18(Predicted)
• CAS DataBase Reference: 3-BROMO-2,4-DIMETHYLPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BROMO-2,4-DIMETHYLPYRIDINE(27063-93-0)
• EPA Substance Registry System: 3-BROMO-2,4-DIMETHYLPYRIDINE(27063-93-0)

Safety Data

• Hazardous Substances Data: 27063-93-0(Hazardous Substances Data)

Usage

General Description

3-Bromo-2,4-dimethylpyridine is a chemical compound with the molecular formula C7H8BrN. It is a derivative of pyridine and is commonly used as a building block in organic synthesis for the production of pharmaceuticals and agrochemicals. 3-BROMO-2,4-DIMETHYLPYRIDINE is a colorless to pale yellow liquid with a strong, pungent odor. It is known for its reactivity as a halogenated pyridine, making it useful in various chemical reactions such as substitution, coupling, and metal complexation reactions. 3-Bromo-2,4-dimethylpyridine is a versatile compound that is widely utilized in the pharmaceutical and agricultural industries for the production of a variety of chemical products.

InChI:InChI=1/C7H8BrN/c1-5-3-4-9-6(2)7(5)8/h3-4H,1-2H3

Upstream product

• 108-47-4 2,4-lutidine 
• 29976-20-3 3,5-dibromo-2,4-dimethylpyridine 

Downstream Products

• 1222184-73-7 3-bromopyridine-2,4-dicarboxylic acid 
• 27063-92-9 5-bromo-2,4-dimethyl-pyridine 

Relevant articles and documents

Inhibition of the histone demethylase JMJD2E by 3-substituted pyridine 2,4-dicarboxylates

Based on structural analysis of the human 2-oxoglutarate (2OG) dependent JMJD2 histone Nε-methyl lysyl demethylase family, 3-substituted pyridine 2,4-dicarboxylic acids were identified as potential inhibitors with possible selectivity over other human 2OG oxygenases. Microwave-assisted palladium-catalysed cross coupling methodology was developed to install a diverse set of substituents on the sterically demanding C-3 position of a pyridine 2,4-dicarboxylate scaffold. The subsequently prepared di-acids were tested for in vitro inhibition of the histone demethylase JMJD2E and another human 2OG oxygenase, prolyl-hydroxylase domain isoform 2 (PHD2, EGLN1). A subset of substitution patterns yielded inhibitors with selectivity for JMJD2E over PHD2, demonstrating that structure-based inhibitor design can enable selective inhibition of histone demethylases over related human 2OG oxygenases.

Substituted pyridine-2,4-dicarboxylic acid derivatives and medicaments based on these compounds

The invention relates to substituted pyridine-2,4-dicarboxylic acid derivatives of the formula I STR1 in which R1 and R2 have the meanings given. The invention also relates to a process for the preparation of the abovementioned compo

SUBSTITUTED ISOCYTOSINES HAVING HISTAMINE H2-ANTAGONIST ACTIVITY

The compounds are substituted isocytosines which are histamine H 2-antagonists. Two specific compounds of the present inventon are 2-2-(5-methyl-4-imidazolylmethylthio)ethylamino!-5-(3-pyridylmethyl)-4-pyrimi done and 2-2-(3-bromo-2-pyridylmethylthio)ethylamino!-5-(4-pyridylmethyl)-4-pyrimidone .