2707-62-2

Basic information

• Product Name: N-Ethyl-3-fluoro-benzenaMine
• Synonyms: N-Ethyl-3-fluoro-benzenaMine;Benzenamine, N-ethyl-3-fluoro-
• CAS NO: 2707-62-2
• Molecular Formula: C₈H₁₀FN
• Molecular Weight: 139.1701032
• Mol File: 2707-62-2.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-Ethyl-3-fluoro-benzenaMine(CAS DataBase Reference)
• NIST Chemistry Reference: N-Ethyl-3-fluoro-benzenaMine(2707-62-2)
• EPA Substance Registry System: N-Ethyl-3-fluoro-benzenaMine(2707-62-2)

Safety Data

• Hazardous Substances Data: 2707-62-2(Hazardous Substances Data)

Upstream product

• 372-19-0 meta-fluoroaniline 
• 109-92-2 ethyl vinyl ether 
• 351-28-0 N-(3-fluorophenyl)acetamide 
• 122-51-0 orthoformic acid triethyl ester 
• 75-07-0 acetaldehyde 

Downstream Products

• 516490-68-9 2-[ethyl(3-fluorophenyl)carbamoyl]cyclopent-2-enecarboxylic acid methyl ester 
• 1422573-62-3 N₆,N₆'-diethyl-N₆,N₆'-di(3-fluorophenyl)-[2,2'-bipyridine]-6,6'-dicarboxamide 
• 55239-53-7 C₉H₉ClFNO 

Relevant articles and documents

Mild catalytic deoxygenation of amides promoted by thorium metallocene

The organoactinide-catalyzed (Cp*2ThMe2) hydroborated reduction of a wide range of tertiary, secondary, and primary amides to the corresponding amines/amine-borane adductsviadeoxygenation of the amides is reported herein. The catalytic reactions proceed under mild conditions with low catalyst loading and pinacolborane (HBpin) concentration in a selective fashion. Cp*2ThMe2is capable of efficiently catalysing the gram-scale reaction without a drop in efficiency. The amine-borane adducts are successfully converted into free amine products in high conversions, which increases the usefulness of this catalytic system. A plausible mechanism is proposed based on detailed kinetics, stoichiometric, and deuterium labeling studies.

Ru-Catalyzed Deoxygenative Transfer Hydrogenation of Amides to Amines with Formic Acid/Triethylamine

A ruthenium(II)-catalyzed deoxygenative transfer hydrogenation of amides to amines using HCO2H/NEt3 as the reducing agent is reported for the first time. The catalyst system consisting of [Ru(2-methylallyl)2(COD)], 1,1,1-tris(diphenylphosphinomethyl) ethane (triphos) and Bis(trifluoromethane sulfonimide) (HNTf2) performed well for deoxygenative reduction of various secondary and tertiary amides into the corresponding amines in high yields with excellent selectivities, and exhibits high tolerance toward functional groups including those that are reduction-sensitive. The choice of hydrogen source and acid co-catalyst is critical for catalysis. Mechanistic studies suggest that the reductive amination of the in situ generated alcohol and amine via borrowing hydrogen is the dominant pathway. (Figure presented.).

Deoxygenative Hydrogenation of Amides Catalyzed by a Well-Defined Iridium Pincer Complex

The iridium-catalyzed highly chemoselective hydrogenation of amides to amines has been developed. Using a well-defined iridium catalyst bearing a P(O)C(O)P pincer ligand combined with B(C6F5)3, the C-O cleavage products are formed under mild reaction conditions. The reaction provides a new method for the preparation of amines from amides in good yield with high selectivity.