27088-84-2

Basic information

• Product Name: 2-(4-methoxyphenyl)-1,3-thiazole
• Synonyms: 2-(4-methoxyphenyl)-1,3-thiazole;2-(4-methoxyphenyl)Thiazole
• CAS NO: 27088-84-2
• Molecular Formula: C₁₀H₉NOS
• Molecular Weight: 191.24956
• EINECS: -0
• Mol File: 27088-84-2.mol
• Article Data: 22

Chemical Properties

• Melting Point: 12-15 °C
• Boiling Point: 156-158 °C(Press: 6 Torr)
• Appearance: /
• Density: 1.184±0.06 g/cm3(Predicted)
• PKA: 2.82±0.10(Predicted)
• CAS DataBase Reference: 2-(4-methoxyphenyl)-1,3-thiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-methoxyphenyl)-1,3-thiazole(27088-84-2)
• EPA Substance Registry System: 2-(4-methoxyphenyl)-1,3-thiazole(27088-84-2)

Safety Data

• Hazardous Substances Data: 27088-84-2(Hazardous Substances Data)

Usage

Type of compound

Thiazole derivative

Structure

Five-membered heterocyclic compound containing a sulfur and nitrogen atom

Usage

Organic synthesis for production of pharmaceuticals and agrochemicals

Unique property

Presence of methoxyphenyl group on the thiazole ring

Importance in drug discovery

Specific chemical and biological activity

Potential applications

Anticancer and antimicrobial properties

Relevance in research

Important target for further study in medicinal chemistry

Upstream product

• 104-92-7 1-bromo-4-methoxy-benzene 
• 1016990-16-1 C₁₀H₉NO₂S 
• 288-47-1 1,3-thiazole 
• 459-64-3 4-methoxybenzenediazonium tetrafluoroborate 
• 914348-82-6 C₁₁H₉NO₂S 
• 5720-07-0 4-methoxyphenylboronic acid 
• 885279-75-4 2-(4-methoxyphenyl)-4-hydroxymethylthiazole 
• 937668-37-6 5-Hydroxymethyl-2-(4-methoxyphenyl)-thiazole 
• 25984-63-8 4-hydroxythiobenzamide 
• 74-83-9 methyl bromide 
• 81015-49-8 2-(4-hydroxyphenyl) thiazole 
• 3034-53-5 2-bromo-1,3-thiazole 
• 171364-79-7 2-(4-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 5053-24-7 2-methylthio-1,3-thiazole 

Downstream Products

• 81015-49-8 2-(4-hydroxyphenyl) thiazole 
• 68004-02-4 2-(4-methoxyphenyl)-5-phenyl-1,3-thiazole 
• 100890-53-7 2-(4-methoxyphenyl)-5-(4-nitrophenyl)thiazole 
• 1000029-08-2 5-iodo-2-(4-methoxyphenyl)thiazole 
• 1000029-27-5 5-(4-chlorophenyl)-2-(4-methoxyphenyl)thiazole 
• 72997-45-6 2,5-bis(4-methoxyphenyl)-1,3-thiazole 
• 163257-18-9 2-methoxy-5-(2-thiazolyl)benzaldehyde 
• 1616428-62-6 2-(4-methoxyphenyl)-5-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiazole 
• 1616428-68-2 C₄₁H₄₄N₆O₄S₃Si 
• 1616428-66-0 2-(4-methoxy-phenyl)-4-bromo-5-methyl-thiazole 
• 1443778-29-7 C₃₂H₂₃N₃OS₃ 
• 1616428-65-9 C₂₉H₂₁N₃OS₃ 
• 1616428-64-8 C₃₀H₂₃N₃OS₃ 

Relevant articles and documents

Syntheses and properties of donor - Acceptor-type 2,5-diarylthiophene and 2,5-diarylthiazole

Equation presented. Syntheses of differently substituted 2,5-diarylthiophenes and 2,5-diarylthiazoles are carried out with the palladium-catalyzed C-H substitution reaction using AgF as an activator. Remarkably strong photoluminescence is observed in 2,5-

Bicyclic alkaloid compound, preparation method and applications thereof

The present invention relates to a bicyclic alkaloid compound, or a tautomer, a stereoisomer, a racemate, the non-equal mixture of enantiomers, a geometric isomer, a solvate, a pharmaceutically acceptable salt or a prodrug thereof, and a pharmaceutical composition containing the compound. The invention further discloses uses of the compounds and the pharmaceutical composition thereof as drugs, especially as anti-inflammatory drugs and anti-fibrotic drugs.

Photon-Quantitative 6π-Electrocyclization of a Diarylbenzo[b]thiophene in Polar Medium

The high reactivity of 6π-electrocyclization in polar solvents has remained one of the important challenges for diarylethenes because of the emergence of a twisted intramolecular charge transfer (TICT) state at the excited state in such polar media, which usually quenches the photocyclization reaction. Herein we report on the preparation and highly efficient photocyclization of 2,3-diarylbenzo[b]thiophenes with nonsymmetric side-aryl units in a polar solvent. While the dithiazolylbenzo[b]thiophene showed a suppressed quantum yield of 6π-electrocyclization of 54% in methanol, the replacement of a thiazole unit with a thiophene ring led to a photon-quantitative 6π-cyclization reaction. The nonsymmetrical modification into the side-aryl units was considered to enhance the CH/π interactions between side-aryl units to support a photoreactive conformation in methanol. The stabilization of the photochromic reactive conformation is expected to suppress the formation of the TICT state at the excited state, leading to highly efficient photoreactivity.