270912-72-6 Usage
Description
(R)-1-Boc-3-(aminomethyl)pyrrolidine, also known as tert-butyl 3-(aminomethyl)pyrrolidine-1-carboxylate, is an organic compound that serves as a valuable intermediate in the field of organic synthesis. It is characterized by its unique molecular structure, which includes a pyrrolidine ring with an aminomethyl group at the 3-position and a tert-butyl carbamate (Boc) protecting group at the 1-position. This structure endows it with specific reactivity and functional group compatibility, making it a versatile building block for the synthesis of various complex organic molecules.
Uses
Used in Pharmaceutical Industry:
(R)-1-Boc-3-(aminomethyl)pyrrolidine is used as a synthetic intermediate for the development of novel pharmaceutical compounds. Its unique structure allows for the creation of new molecules with potential therapeutic applications, such as new drugs for the treatment of various diseases and disorders.
Used in Chemical Research:
In the field of chemical research, (R)-1-Boc-3-(aminomethyl)pyrrolidine is used as a key building block for the synthesis of complex organic molecules. Its reactivity and functional group compatibility make it an attractive candidate for the development of new synthetic routes and methodologies, which can be applied to the preparation of a wide range of target molecules.
Used in Material Science:
(R)-1-Boc-3-(aminomethyl)pyrrolidine can also be utilized in the development of new materials with specific properties. Its unique structure can be incorporated into the design of novel polymers, dendrimers, or other advanced materials with potential applications in various industries, such as electronics, energy storage, or environmental protection.
Check Digit Verification of cas no
The CAS Registry Mumber 270912-72-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,7,0,9,1 and 2 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 270912-72:
(8*2)+(7*7)+(6*0)+(5*9)+(4*1)+(3*2)+(2*7)+(1*2)=136
136 % 10 = 6
So 270912-72-6 is a valid CAS Registry Number.
InChI:InChI=1/C10H20N2O2/c1-10(2,3)14-9(13)12-5-4-8(6-11)7-12/h8H,4-7,11H2,1-3H3/p+1/t8-/m0/s1
270912-72-6Relevant articles and documents
A structure-guided optimization of pyrido[2,3-d]pyrimidin-7-ones as selective inhibitors of EGFRL858R/T790Mmutant with improved pharmacokinetic properties
Yu, Lei,Huang, Minhao,Xu, Tianfeng,Tong, Linjiang,Yan, Xiao-e,Zhang, Zhang,Xu, Yong,Yun, Caihong,Xie, Hua,Ding, Ke,Lu, Xiaoyun
supporting information, p. 1107 - 1117 (2016/12/30)
Structural optimization of pyrido[2,3-d]pyrimidin-7-ones was conducted to yield a series of new selective EGFRT790Minhibitors with improved pharmacokinetic properties. One of the most promising compound 9s potently suppressed EGFRL858R/T790Mkinase and inhibited the proliferation of H1975?cells with IC50values of 2.0?nM and 40?nM, respectively. The compound dose-dependently induced reduction of the phosphorylation of EGFR and downstream activation of ERK in NCI[sbnd]H1975?cells. It also exhibited moderate plasma exposure after oral administration and an oral bioavailability value of 16%. Compound 9s may serve as a promising lead compound for further drug discovery overcoming the acquired resistance of non-small cell lung cancer (NSCLC) patients.
MULTIPLE KINASE PATHWAY INHIBITORS
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Page/Page column 239-241, (2014/04/17)
Kinase with inhibitory activity against kinases disposed in multiple signaling pathways and their therapeutic uses.
BENZIMIDAZOLES AS FATTY ACID SYNTHASE INHIBITORS
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, (2011/06/11)
This invention relates to the use of benzimidazole derivatives for the modulation, notably the inhibition of the activity or function of fatty acid synthase (FAS). Suitably, the present invention relates to the use of benzimidazoles in the treatment of cancer.
