27092-42-8

Basic information

• Product Name: N-1-benzoylindole-3-carboxaldehyde
• Synonyms: N-1-benzoylindole-3-carboxaldehyde
• CAS NO: 27092-42-8
• Molecular Formula: C₁₆H₁₁NO₂
• Molecular Weight: 249.26404
• Mol File: 27092-42-8.mol
• Article Data: 15

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-1-benzoylindole-3-carboxaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: N-1-benzoylindole-3-carboxaldehyde(27092-42-8)
• EPA Substance Registry System: N-1-benzoylindole-3-carboxaldehyde(27092-42-8)

Safety Data

• Hazardous Substances Data: 27092-42-8(Hazardous Substances Data)

Upstream product

• 1496-76-0 N-benzoylindole 
• 75-50-3 trimethylamine 
• 105748-60-5 1-methoxybrassinin 
• 98-88-4 benzoyl chloride 
• 487-89-8 Indole-3-carboxaldehyde 
• 75629-45-7 (Z)-3-(pyrrolidin-1-ylmethylene)-3H-indole 

Downstream Products

• 1370032-20-4 (3E,5E)-3-(4-hydroxybenzylidene)-5-[(1H-indol-3-yl)methylene]-1-methylpiperidin-4-one 
• 1370032-21-5 (3E,5E)-3-(4-hydroxy-3-methoxybenzylidene)-5-[(1H-indol-3-yl)methylene]-1-methylpiperidin-4-one 
• 1370032-19-1 (3E,5E)-3-(3,4-dimethoxybenzylidene)-5-[(1H-indol-3-yl)methylene]-1-methylpiperidin-4-one 
• 1424353-39-8 C₂₀H₁₃N₃O₃S 
• 1365974-57-7 1-benzoyl-3-[(4-fluorophenylimino)methyl]indole 
• 1365974-63-5 1-benzoyl-3-[(4-chlorophenylimino)methyl]indole 
• 1365974-59-9 1-benzoyl-3-[(4-methylphenylimino)methyl]indole 
• 1304522-61-9 1-benzoyl-3-ethenyl-1H-indole 
• 1262149-09-6 1-(1-benzoyl-1H-indol-3-yl)-2-oxopropyl acetate 
• 1262149-28-9 1-(1-benzoyl-1H-indole-3-yl)prop-2-ynyl acetate 
• 1169869-51-5 C₂₂H₁₇N₃O₄ 

Relevant articles and documents

Recyclable and reusablen-Bu4NBF4/PEG-400/H2O system for electrochemical C-3 formylation of indoles with Me3N as a carbonyl source

A safe, practical and eco-friendly electrochemical methodology for the synthesis of 3-formylated indoles has been developed by the utilization of Me3N as a novel formylating reagent. Stoichiometric oxidants, metal catalysts, and activating agents were avoided in this method, and an aqueous biphasic system ofn-Bu4NBF4/PEG-400/H2O was used as a recyclable and reusable reaction medium, which made this electrosynthesis approach more sustainable and environmentally friendly. This process expanded the substrate scope and functional group tolerance for bothN-EDG andN-EWG indoles. Furthermore, late-stage functionalization and total/formal synthesis of drugs and natural products were realized by means of this route.

Spirocyclization reactions and antiproliferative activity of indole phytoalexins 1-methoxybrassinin and its 1-substituted derivatives

The effect of the reaction temperature and the solvent on the diastereoselectivity of the spirocyclization of 1-methoxybrassinin leading to 1-methoxyspirobrassinol methyl ether was studied. 1-Acyl derivatives of 1-methoxyspirobrassinol and 1-methoxyspirobrassinol methyl ether were prepared by the bromine-mediated spirocyclization reactions of derivatives of brassinin bearing an acyl group on the indole nitrogen with water or methanol as nucleophilic agents. The cyclization of 1-Acyl derivatives of brassinin afforded the trans-diastereoisomer as the major product, whereas using 1-methoxybrassinin afforded the cis-And trans-isomers in a ratio near to 1:1. Bromospirocyclization of brassinin and 1-methylbrassinin in the presence of methanol resulted in the formation of spirobrassinin and 1-methylspirobrassinin. The newly synthesized analogues of indole phytoalexins exhibited more significant antiproliferative activity against human leukemia cell lines than the natural phytoalexins.

POLYMERASE, ENDONUCLEASE, AND HELICASE INHIBITORS AND METHODS OF USING THEREOF

Inhibitors of DNA damage polymerases, endonucleases, and helicases are provided. In particular, compounds comprising Formula (I) are described.