271-58-9 Usage
Description
2,1-Benzisoxazole is a heterocyclic compound belonging to the benzoxazole family, characterized by the fusion of a benzene ring to a 1,2-oxazole ring across positions 3 and 4. It is a clear yellow to brown-red liquid and is formed through the thermal decomposition of anthranil, which produces aniline and cyclopentadiene carbonitrile. The surface-enhanced Raman spectrum of anthranil in activated silver colloid has been studied, providing insights into the chemical properties of 2,1-Benzisoxazole.
Uses
Used in Pharmaceutical Industry:
2,1-Benzisoxazole is used as a key intermediate for the synthesis of various pharmaceutical compounds due to its unique chemical structure and properties. Its ability to form stable complexes with other molecules makes it a valuable building block in the development of new drugs.
Used in Chemical Synthesis:
2,1-Benzisoxazole is used as a versatile building block in organic synthesis for the creation of a wide range of chemical compounds. Its unique structure allows for various functional group modifications, making it a valuable component in the synthesis of complex organic molecules.
Used in Material Science:
2,1-Benzisoxazole is used as a component in the development of novel materials with specific properties, such as improved stability, reactivity, or selectivity. Its unique chemical structure contributes to the overall performance of these materials, making it an important component in material science research and development.
Used in Research and Development:
2,1-Benzisoxazole is used as a research tool in the study of various chemical reactions and processes, as well as in the development of new synthetic methods and techniques. Its unique properties and reactivity make it an important compound for researchers in the field of chemistry and related disciplines.
Check Digit Verification of cas no
The CAS Registry Mumber 271-58-9 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 2,7 and 1 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 271-58:
(5*2)+(4*7)+(3*1)+(2*5)+(1*8)=59
59 % 10 = 9
So 271-58-9 is a valid CAS Registry Number.
InChI:InChI=1/C7H5NO/c1-2-4-7-6(3-1)5-9-8-7/h1-5H
271-58-9Relevant articles and documents
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Bamberger
, p. 814 (1924)
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The Elimination of Masses 27 and 28 from the + Ion of 2-Nitrotoluene
Herbert, C. G.,Larka, E. A.,Beynon, J. H.
, p. 306 - 310 (1984)
The expulsion of neutral fragments of masses 27 and 28 from metastable + ions derived from 2-nitrotoluene has been observed.The relative abundances of the resulting fragment ions, together with the kinetic energy released in each process, has been compared with similar fragmentations of + ions derived from other precursor molecules.In this way, the nature of the neutral fragments and the structure of the + ions from 2-nitrotoluene has been investigated.The most likely structure is the 1,2-benzisoxazolenium cation although the coexistence of other structures cannot be ruled out on the present evidence.
Palladium-catalyzed carbonylative cyclization of benzyl chlorides with anthranils for the synthesis of 3-arylquinolin-2(1: H)-ones
Liu, Jian-Li,Xu, Ren-Rui,Wang, Wei,Qi, Xinxin,Wu, Xiao-Feng
supporting information, p. 3584 - 3588 (2021/05/04)
An efficient carbonylative procedure for the synthesis of 3-arylquinoin-2(1H)-ones has been established. Through a palladium-catalyzed aminocarbonylation of benzyl chlorides with anthranils, a variety of 3-arylquinoin-2(1H)-one products were obtained in moderate to excellent yields with good functional group tolerance. This journal is
Access to acridones by tandem copper(i)-catalyzed electrophilic amination/Ag(i)-mediated oxidative annulation of anthranils with arylboronic acids
Huang, Yan-Xia,Huang, Zhuo-Jun,Jiang, Chun-Yong,Liang, Jing-Yi,Liang, Qiu-Ping,Shu, Bing,Xie, Hui,Zeng, Jun-Yi,Zhang, Shang-Shi,Zhou, Binhua
supporting information, p. 8487 - 8491 (2021/10/20)
An efficient and practical approach for the synthesis of medicinally important acridones was developed from anthranils and commercially available arylboronic acids by a tandem copper(i)-catalyzed electrophilic amination/Ag(i)-mediated oxidative annulation strategy. This new and straightforward protocol displayed a broad substrate scope (25 examples) and high functional group tolerance. What's more, a possible mechanistic proposal was also presented.
