27162-74-9

Basic information

• Product Name: 1,3-Bis(heptafluoro-2-propyl)benzene
• Synonyms: 1,3-Bis(heptafluoro-2-propyl)benzene
• CAS NO: 27162-74-9
• Molecular Weight: 414.141
• Mol File: 27162-74-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1,3-Bis(heptafluoro-2-propyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Bis(heptafluoro-2-propyl)benzene(27162-74-9)
• EPA Substance Registry System: 1,3-Bis(heptafluoro-2-propyl)benzene(27162-74-9)

Safety Data

• Hazardous Substances Data: 27162-74-9(Hazardous Substances Data)

Upstream product

• 677-69-0 perfluoroisopropyl iodide 
• 108-36-1 1,3-dibromobenzene 

Relevant articles and documents

Mechanistically Guided Design of Ligands That Significantly Improve the Efficiency of CuH-Catalyzed Hydroamination Reactions

Using a mechanically guided ligand design approach, a new ligand (SEGFAST) for the CuH-catalyzed hydroamination reaction of unactivated terminal olefins has been developed, providing a 62-fold rate increase over reactions compared to DTBM-SEGPHOS, the previous optimal ligand. Combining the respective strengths of computational chemistry and experimental kinetic measurements, we were able to quickly identify potential modifications that lead to more effective ligands, thus avoiding synthesizing and testing a large library of ligands. By optimizing the combination of attractive, noncovalent ligand-substrate interactions and the stability of the catalyst under the reaction conditions, we were able to identify a finely tuned hybrid ligand that greatly enables accelerated hydrocupration rates with unactivated alkenes. Moreover, a modular and robust synthetic sequence was devised, which allowed for the practical, gram-scale synthesis of these novel hybrid ligand structures.

Catalytic asymmetric [4+2]-cycloaddition of dienes with aldehydes

Despite its significant potential, a general catalytic asymmetric [4+2]-cycloaddition of simple and electronically unbiased dienes with any type of aldehyde has long been unknown. Previously developed methodologies invariably require activated, electronically engineered substrates. We now provide a general solution to this problem. We show that highly acidic and confined imidodiphosphorimidates (IDPis) are extremely effective Br?nsted acid catalysts of the hetero-Diels-Alder reaction of a wide variety of aldehydes and dienes to give enantiomerically enriched dihydropyrans. Excellent stereoselectivity is generally observed and a variety of scents and natural products can be easily accessed.