272129-63-2

Basic information

• Product Name: 1-tert-butoxycarbonyl-2(S)-[2-phenylsulphonyl-(E)-ethenyl]pyrrolidine
• Synonyms: 1-tert-butoxycarbonyl-2(S)-[2-phenylsulphonyl-(E)-ethenyl]pyrrolidine
• CAS NO: 272129-63-2
• Molecular Weight: 337.44
• Mol File: 272129-63-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-tert-butoxycarbonyl-2(S)-[2-phenylsulphonyl-(E)-ethenyl]pyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-tert-butoxycarbonyl-2(S)-[2-phenylsulphonyl-(E)-ethenyl]pyrrolidine(272129-63-2)
• EPA Substance Registry System: 1-tert-butoxycarbonyl-2(S)-[2-phenylsulphonyl-(E)-ethenyl]pyrrolidine(272129-63-2)

Safety Data

• Hazardous Substances Data: 272129-63-2(Hazardous Substances Data)

Upstream product

• 56069-39-7 diethyl phenylsulfonylmethylphosphonate 
• 69610-41-9 Boc-L-Pro-H 

Relevant articles and documents

Synthesis and activity of pyrrolidinyl- and thiazolidinyl-dipeptide derivatives as inhibitors of the Tc80 prolyl oligopeptidase from Trypanosoma cruzi

Pyrrolidinyl- and thiazolidinyl- dipeptide derivatives, featuring either a vinyl sulfone-, a 2-ketobenzothiazole-, a nitrile-, or a benzimidazole group at the C-terminus, were designed and synthesized as potential inhibitors of the prolyl-specific Tc80 proteinase from Trypanosoma cruzi, the agent of Chagas' disease. These compounds were evaluated in vitro towards the target enzyme which was classified as a serine protease belonging to the prolyl oligopeptidase family (EC 3.4.21.26). A peptidyl nitrile and two peptidyl α-ketobenzothiazoles were shown to be potent reversible and competitive inhibitors of Tc 80 proteinase, with K(i) values in the range 38- 219 nM, and compared advantageously with some known mammalian prolyl oligopeptidase inhibitors. (C) 2000 Editions scientifiques et medicales Elsevier SAS.