272130-53-7

Basic information

• Product Name: 3-(3-hydroxy-prop-1-ynyl)-4-methyl-benzoic acid methyl ester
• Synonyms: 3-(3-hydroxy-prop-1-ynyl)-4-methyl-benzoic acid methyl ester
• CAS NO: 272130-53-7
• Molecular Weight: 204.225
• Mol File: 272130-53-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(3-hydroxy-prop-1-ynyl)-4-methyl-benzoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3-hydroxy-prop-1-ynyl)-4-methyl-benzoic acid methyl ester(272130-53-7)
• EPA Substance Registry System: 3-(3-hydroxy-prop-1-ynyl)-4-methyl-benzoic acid methyl ester(272130-53-7)

Safety Data

• Hazardous Substances Data: 272130-53-7(Hazardous Substances Data)

Upstream product

• 90347-66-3 methyl 3-iodo-4-methylbenzoate 
• 107-19-7 propargyl alcohol 

Downstream Products

• 1027396-72-0 4-methyl-3-[3-(8-oxo-7,8-dihydro-6H-imidazo[4,5-d][1,3]diazepin-3-yl)-propyl]-benzoic acid methyl ester 
• 165801-58-1 3-[3-(8-hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]diazepin-3-yl)-propyl]-4-methyl-benzoic acid methyl ester 
• 272130-55-9 3-(3-bromo-propyl)-4-methyl-benzoic acid methyl ester 

Relevant articles and documents

AMP deaminase inhibitors. 3. SAR of 3-(carboxyarylalkyl)coformycin aglycon analogues

N3-Substituted coformycin aglycon analogues with improved AMP deaminase (AMPDA) inhibitory potency are described. Replacement of the 5-carboxypentyl substituent in the lead AMPDA inhibitor 3-(5-carboxypentyl)-3,6,7,8- tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol (2) described in the previous article with various carboxyarylalkyl groups resulted in compounds with 10- 100-fold improved AMPDA inhibitory potencies. The optimal N3 substituent had m-carboxyphenyl with a two-carbon alkyl tether. For example, 3-[2-(3-carboxy- 5-ethylphenyl)ethyl]-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol (43g) inhibited human AMPDA with a K(i) = 0.06 μM. The compounds within the series also exhibited > 1000-fold specificity for AMPDA relative to adenosine deaminase.