27259-73-0Relevant articles and documents
A new fluorescent probe for ultrasensitive detection of phosgene in solution and the gas phase
Zeng, Fenfen,Bao, Guangbo,Zhou, Baocheng,Han, Yifeng
, p. 5631 - 5636 (2021)
Due to the high toxicity and commercial availability of phosgene, it is urgent to detect phosgene quickly and reliably to deal with its potential serious threat to public safety. A new 2-(2-aminophenyl)quinazolin-4(3H)-one (APQ) based fluorescent probeAPQhas been developed as a rapid, highly sensitive, and selective sensor for phosgene in this work.APQdisplays very weak fluorescence in acetonitrile due to the free rotation of the 2-aminophenyl moiety. After reacting with phosgene,APQis converted to a new restricted intramolecular motion productAPQU1. Owing to the specific cyclization reactions,APQexhibits an obvious fluorescence response toward phosgene with a large Stokes shift (104 nm), instant response (less than 20 s), and low detection limit (0.16 ppm). Moreover, theAPQ-loaded test strip was prepared and demonstrated to have practical utility in detecting phosgene vapor.
Palladium(II) N^O Chelating Complexes Catalyzed One-Pot Approach for Synthesis of Quinazolin-4(3 H)-ones via Acceptorless Dehydrogenative Coupling of Benzyl Alcohols and 2-Aminobenzamide
Balaji, Sundarraman,Balamurugan, Gunasekaran,Ramesh, Rengan,Semeril, David
, p. 725 - 734 (2021/04/06)
A convenient protocol for the one-pot synthesis of quinazolin-4(3H)-ones using palladium(II) complexes via dehydrogenative coupling of readily available benzyl alcohols and 2-aminobenzamide has been described. New structurally related Pd(II) N^O chelating complexes of general configuration [Pd(L)Cl(PPh3)] (where L = dimethylamino benzoylhydrazone ligands) have been designed and synthesized. The formation of the complexes has been recognized by analytical and spectral methods (FT-IR, NMR, HR-MS). The presence of a square-planar geometry around the palladium(II) ion was confirmed by single crystal X-ray diffraction study. A wide range of substituted quinazolinones have been successfully achieved from a diverse range of benzyl alcohols in good to excellent yields using 1.0 mol % of catalyst loading under aerobic conditions. Furthermore, control experiments reveal that the dehydrogenative coupling reaction involves initially the formation of an aldehyde intermediate and subsequent formation of a cyclic aminal intermediate.
Luotonin A and Its Derivatives as Novel Antiviral and Antiphytopathogenic Fungus Agents
Hao, Yanan,Liu, Yuxiu,Ma, Dejun,Wang, Kaihua,Wang, Qingmin,Wang, Ziwen
, p. 8764 - 8773 (2020/09/16)
Plant diseases caused by viruses and fungi have posed a serious threat to global agricultural production. The discovery of new leads based on natural products is an important way to innovate pesticides. In this work, natural product luotonin A was found to have good antiviral activity against tobacco mosaic virus (TMV) for the first time. A series of luotonin A derivatives were designed, synthesized, and evaluated for their antiviral activities and fungicidal activities systematically. Most compounds displayed better antiviral activities against TMV than commercial ribavirin. Compounds 9k, 12b, and 12d displayed about similar inhibitory effects as ningnanmycin (inhibitory rates of 55, 57, and 59% at 500 μg/mL for inactivation, curative, and protection activities in vivo, respectively), the best antiviral agent at present, and emerged as novel antiviral leads for further research. We selected 9k for further antiviral mechanism research via transmission electron microscopy and molecular docking, which revealed that compound 9k can interact with TMV coat protein through the hydrogen bond, leading to its polymerization, thus preventing virus assembly. Further fungicidal activity tests showed that these compounds also showed broad-spectrum fungicidal activities against 14 kinds of phytopathogenic fungi. Especially, compound 14 with a 100% antifungal effect against Botrytis cinereal emerged as a lead for further research. This work provides a reference for the development of agricultural active ingredients based on Chinese medicine plants.
