2729-34-2

Basic information

• Product Name: 3,5-dichloro-4-fluoroaniline
• Synonyms: 3,5-dichloro-4-fluoroaniline;3,5-Dichloro-4-fluorobenzenamine;(3,5-dichloro-4-fluoro-phenyl)amine
• CAS NO: 2729-34-2
• Molecular Formula: C₆H₄Cl₂FN
• Molecular Weight: 180.0070632
• EINECS: 220-345-2
• Product Categories: CHIRAL CHEMICALS
• Mol File: 2729-34-2.mol
• Article Data: 5

Chemical Properties

• Melting Point: 100-101°C
• Boiling Point: 287.172 °C at 760 mmHg
• Flash Point: 127.477 °C
• Appearance: /
• Density: 1.502 g/cm³
• Vapor Pressure: 0.00252mmHg at 25°C
• Refractive Index: 1.587
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 2.54±0.10(Predicted)
• CAS DataBase Reference: 3,5-dichloro-4-fluoroaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-dichloro-4-fluoroaniline(2729-34-2)
• EPA Substance Registry System: 3,5-dichloro-4-fluoroaniline(2729-34-2)

Safety Data

• Hazardous Substances Data: 2729-34-2(Hazardous Substances Data)

Usage

Chemical Properties

off-white powder

InChI:InChI=1/C6H4Cl2FN/c7-4-1-3(10)2-5(8)6(4)9/h1-2H,10H2

Synthetic route

3,5-dichloro-4-fluoro-nitrobenzene (3107-19-5) → 3,5-dichloro-4-fluorophenylamine (2729-34-2)

Conditions	Yield
With hydrogen In methanol Inert atmosphere;	90%
With hydrogenchloride; tin(ll) chloride
With ammonium formate; zinc In methanol; water for 1.33333h;

3,4,5-trichloronitrobenzen (20098-48-0) → 3,5-dichloro-4-fluorophenylamine (2729-34-2)

Conditions	Yield
Multi-step reaction with 2 steps 1: dimethylformamide; potassium fluoride / 150 °C 2: SnCl2; aqueous HCl View Scheme
Multi-step reaction with 2 steps 1: potassium fluoride; N-benzyl-N,N,N-triethylammonium chloride / 11 h / 140 - 175 °C 2: hydrogen / methanol / Inert atmosphere View Scheme

3,5-dichloro-4-fluorophenylamine (2729-34-2) → 1,3-dichloro-2-fluorobenzene (2268-05-5)

Conditions	Yield
Stage #1: 3,5-dichloro-4-fluorophenylamine With nitrosylsulfuric acid at 10 - 15℃; for 6h; Stage #2: With copper(I) oxide; sodium hypophosphite; sulfuric acid; water for 1h;	86%

2-amino-6-methyl-4-chloropyrimidine (5600-21-5) + 3,5-dichloro-4-fluorophenylamine (2729-34-2) → N4-(3,5-dichloro-4-fluorophenyl)-6-methylpyrimidine-2,4-diamine

Conditions	Yield
With hydrogenchloride In ethanol; water at 140℃; for 1.5h; Microwave irradiation; Sealed tube;	81%

2,4-dichloro-5-(morpholinosulfonyl)benzoyl chloride + 3,5-dichloro-4-fluorophenylamine (2729-34-2) → 2,4-dichloro-N-(3,5-dichloro-4-fluorophenyl)-5-(morpholinosulfonyl)benzamide

Conditions	Yield
With pyridine In dichloromethane at 20℃; for 12h; Inert atmosphere;	76%

3,5-dichloro-4-fluorophenylamine (2729-34-2) + 2,4-dichloro-5-[(4-methylpiperazin-1-yl)sulfonyl]benzoyl chloride → 2,4-dichloro-N-(3,5-dichloro-4-fluorophenyl)-5-((4-methylpiperazin-1-yl)sulfonyl)benzamide

Conditions	Yield
With pyridine In dichloromethane at 20℃; for 12h; Inert atmosphere;	64%

3,5-dichloro-4-fluorophenylamine (2729-34-2) + potassium ethyl xanthogenate (140-89-6) → O-ehyl (3,5-dichloro-4-fluorophenyl)sulfanylmethanethioate

Conditions	Yield
Stage #1: 3,5-dichloro-4-fluorophenylamine With hydrogenchloride; sodium nitrite In water at -5℃; Stage #2: potassium ethyl xanthogenate In water at 50℃; for 3h;	60%
With hydrogenchloride; sodium nitrite In water at 0 - 70℃; for 2h;

3,5-dichloro-4-fluorophenylamine (2729-34-2) + phenyl chloroformate (1885-14-9) → phenyl (3,5-dichloro-4-fluorophenyl)carbamate

Conditions	Yield
With pyridine In tetrahydrofuran at 0 - 20℃; for 16h; Inert atmosphere;	55%
With sodium hydrogencarbonate In water; ethyl acetate

4-[5-bromo-2-(4-methoxybenzyl)-2H-[1,2,4]triazol-3-yl]morpholine + 3,5-dichloro-4-fluorophenylamine (2729-34-2) → (3,5-dichloro-4-fluorophenyl)-[1-(4-methoxybenzyl)-5-morpholin-4-yl-1H-[1,2,4]triazol-3-yl]amine

Conditions	Yield
With tris-(dibenzylideneacetone)dipalladium(0); sodium t-butanolate; tert-butyl XPhos In toluene at 20 - 85℃; for 15.0833h; Inert atmosphere;	53%

1-benzyl-5-bromo-1H-[1,2,4]triazole + 3,5-dichloro-4-fluorophenylamine (2729-34-2) → (2-benzyl-2H-[1,2,4]triazol-3-yl)(3,5-dichloro-4-fluorophenyl)amine

Conditions	Yield
With tris-(dibenzylideneacetone)dipalladium(0); sodium t-butanolate; tert-butyl XPhos In toluene at 110℃; for 18h; Inert atmosphere;	15%

2-acetylpropanoic acid ethyl ester (609-14-3) + 3,5-dichloro-4-fluorophenylamine (2729-34-2) → ethyl (2Z)-2-[2-(3,5-dichloro-4-fluorophenyl)hydrazin-1-ylidene]propanoate

Conditions	Yield
Stage #1: 3,5-dichloro-4-fluorophenylamine With hydrogenchloride; sodium nitrite In ethanol; water at 0℃; for 0.0833333h; Stage #2: 2-acetylpropanoic acid ethyl ester In ethanol; water at -10℃; for 0.05h;	14.7%

1-benzyl-3-bromo-1H-[1,2,4]triazole + 3,5-dichloro-4-fluorophenylamine (2729-34-2) → (1-benzyl-1H-[1,2,4]triazol-3-yl)-(3,5-dichloro-4-fluorophenyl)amine

Conditions	Yield
With tris-(dibenzylideneacetone)dipalladium(0); sodium t-butanolate; tert-butyl XPhos In toluene at 110℃; for 19h; Inert atmosphere;	7%

3,5-dichloro-4-fluorophenylamine (2729-34-2) + ethyl cyanoacetimidate hydrochloride (55244-11-6) → N5-(3,5-dichloro-4-fluoro-phenyl)-1H-pyrazole-3,5-diamine

Conditions	Yield
Stage #1: 3,5-dichloro-4-fluorophenylamine; ethyl cyanoacetimidate hydrochloride In ethanol at 20℃; under 760.051 Torr; Inert atmosphere; Stage #2: With hydrazine In ethanol; water under 760.051 Torr; for 4.5h; Inert atmosphere; Heating;	5%

3,5-dichloro-4-fluorophenylamine (2729-34-2) → 3,5-dichloro-4-fluorophenol (2995-04-2)

Conditions	Yield
Stage #1: 3,5-dichloro-4-fluorophenylamine With sulfuric acid; sodium nitrite In water at 0℃; for 0.166667h; Stage #2: With sulfuric acid; water; sodium sulfate at 90 - 120℃; for 2.5h; Enzymatic reaction;	5%

Boc-(R)-Ala (3744-87-4, 7764-95-6, 15761-38-3) + 3,5-dichloro-4-fluorophenylamine (2729-34-2) → [(R)-1-(3,5-dichloro-4-fluoro-phenylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester (1159735-51-9)

Conditions	Yield
Stage #1: Boc-(R)-Ala With 4-methyl-morpholine; isobutyl chloroformate In tetrahydrofuran at -20 - -15℃; for 0.833333h; Stage #2: 3,5-dichloro-4-fluorophenylamine In tetrahydrofuran at 20℃; for 20h;
With 4-methyl-morpholine; isobutyl chloroformate In tetrahydrofuran at -20 - 20℃;
Stage #1: Boc-(R)-Ala With 4-methyl-morpholine; isobutyl chloroformate In tetrahydrofuran at -20 - -15℃; for 0.833333h; Stage #2: 3,5-dichloro-4-fluorophenylamine In tetrahydrofuran at -15 - 20℃;

3,5-dichloro-4-fluorophenylamine (2729-34-2) + Kalium-ethyl-adipat (24356-36-3) → C14H15Cl2FN2O4 (1570075-05-6)

Conditions	Yield
Stage #1: 3,5-dichloro-4-fluorophenylamine With hydrogenchloride; sodium nitrite In water at 0 - 8℃; for 0.333333h; Stage #2: Kalium-ethyl-adipat In water at 0 - 40℃; for 1h; Japp-Klingemann Hydrazone Synthesis;

4-[5-bromo-2-(4-methoxybenzyl)-2H-[1,2,4]triazol-3-yl]morpholine + 3,5-dichloro-4-fluorophenylamine (2729-34-2) → (3,5-dichloro-4-fluorophenyl)-(5-morpholin-4-yl-1H-[1,2,4]triazol-3-yl)amine

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium(0); tert-butyl XPhos / toluene / 15.08 h / 20 - 85 °C / Inert atmosphere 2: trifluoroacetic acid / 2 h / 65 °C View Scheme

4-chlorosulfonyl-1-methyl-pyrrole-2-carbonyl chloride + 3,5-dichloro-4-fluorophenylamine (2729-34-2) → 5-[(3,5-dichloro-4-fluorophenyl)carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride

Conditions	Yield
In toluene for 2h; Reflux;

3,5-dichloro-4-fluorophenylamine (2729-34-2) → tert-butyl N'-cyclopropylcarbonyl-N-{2-chloro-5-[5-(3,5-dichloro-4-fluorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}carbazate

Conditions

Yield

Multi-step reaction with 7 steps 1.1: sodium nitrite; acetic acid; sulfuric acid / 4 h / 20 °C / Cooling with ice 1.2: 1 h / 70 °C / Cooling with ice 2.1: isopropylmagnesium chloride / tetrahydrofuran / 1.33 h / Cooling with ice 2.2: 1.83 h / Cooling with ice 3.1: triethylamine / tetrahydrofuran / 2 h / 60 - 80 °C 4.1: dmap; acetic anhydride; triethylamine / toluene / 3 h / 50 °C 5.1: sodium hydroxide; tetrabutylammomium bromide; hydroxylamine hydrochloride / water; tert-butyl methyl ether / 1 h / 20 °C / Cooling with ice 6.1: sodium hydroxide; ammonium hydroxide; ammonium chloride; Aliquat 336; sodium hypochlorite / tetrahydrofuran; water / 0.67 h / 20 °C 7.1: triethylamine / tetrahydrofuran / 0.08 h / 20 °C View Scheme

3,5-dichloro-4-fluorophenylamine (2729-34-2) → N'-{2-chloro-5-[5-(3,5-dichloro-4-fluorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}cyclopropanecarbohydrazide

Conditions

Yield

Multi-step reaction with 8 steps 1.1: sodium nitrite; acetic acid; sulfuric acid / 4 h / 20 °C / Cooling with ice 1.2: 1 h / 70 °C / Cooling with ice 2.1: isopropylmagnesium chloride / tetrahydrofuran / 1.33 h / Cooling with ice 2.2: 1.83 h / Cooling with ice 3.1: triethylamine / tetrahydrofuran / 2 h / 60 - 80 °C 4.1: dmap; acetic anhydride; triethylamine / toluene / 3 h / 50 °C 5.1: sodium hydroxide; tetrabutylammomium bromide; hydroxylamine hydrochloride / water; tert-butyl methyl ether / 1 h / 20 °C / Cooling with ice 6.1: sodium hydroxide; ammonium hydroxide; ammonium chloride; Aliquat 336; sodium hypochlorite / tetrahydrofuran; water / 0.67 h / 20 °C 7.1: triethylamine / tetrahydrofuran / 0.08 h / 20 °C 8.1: trifluoroacetic acid / 2 h / 50 °C View Scheme

3,5-dichloro-4-fluorophenylamine (2729-34-2) → tert-butyl N'-2-fluorocyclopropylcarbonyl-N-{2-chloro-5-[5-(3,5-dichloro-4-fluorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}carbazate

Conditions

Yield

Multi-step reaction with 7 steps 1.1: sodium nitrite; acetic acid; sulfuric acid / 4 h / 20 °C / Cooling with ice 1.2: 1 h / 70 °C / Cooling with ice 2.1: isopropylmagnesium chloride / tetrahydrofuran / 1.33 h / Cooling with ice 2.2: 1.83 h / Cooling with ice 3.1: triethylamine / tetrahydrofuran / 2 h / 60 - 80 °C 4.1: dmap; acetic anhydride; triethylamine / toluene / 3 h / 50 °C 5.1: sodium hydroxide; tetrabutylammomium bromide; hydroxylamine hydrochloride / water; tert-butyl methyl ether / 1 h / 20 °C / Cooling with ice 6.1: sodium hydroxide; ammonium hydroxide; ammonium chloride; Aliquat 336; sodium hypochlorite / tetrahydrofuran; water / 0.67 h / 20 °C 7.1: N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; benzotriazol-1-ol / N,N-dimethyl-formamide / 1.5 h / 50 °C View Scheme

3,5-dichloro-4-fluorophenylamine (2729-34-2) → N'-{2-chloro-5-[5-(3,5-dichloro-4-fluorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}-2-fluorocyclopropanecarbohydrazide

Conditions

Yield

Multi-step reaction with 8 steps 1.1: sodium nitrite; acetic acid; sulfuric acid / 4 h / 20 °C / Cooling with ice 1.2: 1 h / 70 °C / Cooling with ice 2.1: isopropylmagnesium chloride / tetrahydrofuran / 1.33 h / Cooling with ice 2.2: 1.83 h / Cooling with ice 3.1: triethylamine / tetrahydrofuran / 2 h / 60 - 80 °C 4.1: dmap; acetic anhydride; triethylamine / toluene / 3 h / 50 °C 5.1: sodium hydroxide; tetrabutylammomium bromide; hydroxylamine hydrochloride / water; tert-butyl methyl ether / 1 h / 20 °C / Cooling with ice 6.1: sodium hydroxide; ammonium hydroxide; ammonium chloride; Aliquat 336; sodium hypochlorite / tetrahydrofuran; water / 0.67 h / 20 °C 7.1: N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; benzotriazol-1-ol / N,N-dimethyl-formamide / 1.5 h / 50 °C 8.1: trifluoroacetic acid / 2 h / 20 °C View Scheme

3,5-dichloro-4-fluorophenylamine (2729-34-2) → tert-butyl 2,2-difluorocyclopropanecarbonyl-N-{2-chloro-5-[5-(3,5-dichloro-4-fluorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}carbazate

Conditions

Yield

Multi-step reaction with 7 steps 1.1: sodium nitrite; acetic acid; sulfuric acid / 4 h / 20 °C / Cooling with ice 1.2: 1 h / 70 °C / Cooling with ice 2.1: isopropylmagnesium chloride / tetrahydrofuran / 1.33 h / Cooling with ice 2.2: 1.83 h / Cooling with ice 3.1: triethylamine / tetrahydrofuran / 2 h / 60 - 80 °C 4.1: dmap; acetic anhydride; triethylamine / toluene / 3 h / 50 °C 5.1: sodium hydroxide; tetrabutylammomium bromide; hydroxylamine hydrochloride / water; tert-butyl methyl ether / 1 h / 20 °C / Cooling with ice 6.1: sodium hydroxide; ammonium hydroxide; ammonium chloride; Aliquat 336; sodium hypochlorite / tetrahydrofuran; water / 0.67 h / 20 °C 7.1: N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; benzotriazol-1-ol / N,N-dimethyl-formamide / 2.5 h / 50 - 70 °C View Scheme

3,5-dichloro-4-fluorophenylamine (2729-34-2) → tert-butyl N'-isovaleryl-N-{2-chloro-5-[5-(3,5-dichloro-4-fluorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}carbazate

Conditions

Yield

Multi-step reaction with 7 steps 1.1: sodium nitrite; acetic acid; sulfuric acid / 4 h / 20 °C / Cooling with ice 1.2: 1 h / 70 °C / Cooling with ice 2.1: isopropylmagnesium chloride / tetrahydrofuran / 1.33 h / Cooling with ice 2.2: 1.83 h / Cooling with ice 3.1: triethylamine / tetrahydrofuran / 2 h / 60 - 80 °C 4.1: dmap; acetic anhydride; triethylamine / toluene / 3 h / 50 °C 5.1: sodium hydroxide; tetrabutylammomium bromide; hydroxylamine hydrochloride / water; tert-butyl methyl ether / 1 h / 20 °C / Cooling with ice 6.1: sodium hydroxide; ammonium hydroxide; ammonium chloride; Aliquat 336; sodium hypochlorite / tetrahydrofuran; water / 0.67 h / 20 °C 7.1: N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; benzotriazol-1-ol / N,N-dimethyl-formamide / 4 h / 50 °C View Scheme

3,5-dichloro-4-fluorophenylamine (2729-34-2) → tert-butyl N-{2-chloro-5-[5-(3,5-dichloro-4-fluorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}carbamate

Conditions

Yield

Multi-step reaction with 5 steps 1.1: sodium nitrite; acetic acid; sulfuric acid / 4 h / 20 °C / Cooling with ice 1.2: 1 h / 70 °C / Cooling with ice 2.1: isopropylmagnesium chloride / tetrahydrofuran / 1.33 h / Cooling with ice 2.2: 1.83 h / Cooling with ice 3.1: triethylamine / tetrahydrofuran / 2 h / 60 - 80 °C 4.1: dmap; acetic anhydride; triethylamine / toluene / 3 h / 50 °C 5.1: sodium hydroxide; tetrabutylammomium bromide; hydroxylamine hydrochloride / water; tert-butyl methyl ether / 1 h / 20 °C / Cooling with ice View Scheme

3,5-dichloro-4-fluorophenylamine (2729-34-2) → tert-butyl N-{2-chloro-5-[3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluoro-2-butenoyl]phenyl}carbamate

Conditions	Yield
Multi-step reaction with 4 steps 1.1: sodium nitrite; acetic acid; sulfuric acid / 4 h / 20 °C / Cooling with ice 1.2: 1 h / 70 °C / Cooling with ice 2.1: isopropylmagnesium chloride / tetrahydrofuran / 1.33 h / Cooling with ice 2.2: 1.83 h / Cooling with ice 3.1: triethylamine / tetrahydrofuran / 2 h / 60 - 80 °C 4.1: dmap; acetic anhydride; triethylamine / toluene / 3 h / 50 °C View Scheme

3,5-dichloro-4-fluorophenylamine (2729-34-2) → tert-butyl N-{2-chloro-5-[3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluoro-3-hydroxy-butanoyl]phenyl}carbamate

Conditions	Yield
Multi-step reaction with 3 steps 1.1: sodium nitrite; acetic acid; sulfuric acid / 4 h / 20 °C / Cooling with ice 1.2: 1 h / 70 °C / Cooling with ice 2.1: isopropylmagnesium chloride / tetrahydrofuran / 1.33 h / Cooling with ice 2.2: 1.83 h / Cooling with ice 3.1: triethylamine / tetrahydrofuran / 2 h / 60 - 80 °C View Scheme

3,5-dichloro-4-fluorophenylamine (2729-34-2) → 1-(3,5-dichloro-4-fluorophenyl)-2,2,2-trifluoroethan-1-one (1190865-44-1)

Conditions	Yield
Multi-step reaction with 2 steps 1.1: sodium nitrite; acetic acid; sulfuric acid / 4 h / 20 °C / Cooling with ice 1.2: 1 h / 70 °C / Cooling with ice 2.1: isopropylmagnesium chloride / tetrahydrofuran / 1.33 h / Cooling with ice 2.2: 1.83 h / Cooling with ice View Scheme

3,5-dichloro-4-fluorophenylamine (2729-34-2) → 1,3-dichloro-2-fluoro-5-iodo-benzene

Conditions	Yield
Stage #1: 3,5-dichloro-4-fluorophenylamine With sulfuric acid; acetic acid; sodium nitrite at 20℃; for 4h; Cooling with ice; Stage #2: With potassium iodide at 70℃; for 1h; Cooling with ice;	29.7 g

3,5-dichloro-4-fluorophenylamine (2729-34-2) → tert-butyl N-{2-chloro-5-[5-(3,5-dichloro-4-fluorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}carbazate

Conditions

Yield

Multi-step reaction with 6 steps 1.1: sodium nitrite; acetic acid; sulfuric acid / 4 h / 20 °C / Cooling with ice 1.2: 1 h / 70 °C / Cooling with ice 2.1: isopropylmagnesium chloride / tetrahydrofuran / 1.33 h / Cooling with ice 2.2: 1.83 h / Cooling with ice 3.1: triethylamine / tetrahydrofuran / 2 h / 60 - 80 °C 4.1: dmap; acetic anhydride; triethylamine / toluene / 3 h / 50 °C 5.1: sodium hydroxide; tetrabutylammomium bromide; hydroxylamine hydrochloride / water; tert-butyl methyl ether / 1 h / 20 °C / Cooling with ice 6.1: sodium hydroxide; ammonium hydroxide; ammonium chloride; Aliquat 336; sodium hypochlorite / tetrahydrofuran; water / 0.67 h / 20 °C View Scheme

Upstream product

• 20098-48-0 3,4,5-trichloronitrobenzen 
• 3107-19-5 3,5-dichloro-4-fluoro-nitrobenzene 

Downstream Products

• 2995-04-2 3,5-dichloro-4-fluorophenol 
• 1159738-06-3 1-{[(R)-5-(4-Cyano-benzyl)-7-(3,5-dichloro-4-fluoro-phenyl)-5-methyl-6-oxo-6,7-dihydro-5H-imidazo[1,2-α]imidazole-3-carbonyl]-amino}-cyclopropanecarboxylic acid 
• 1257638-06-4 (R)-5-(4-cyano-benzyl)-7-(3,5-dichloro-4-fluoro-phenyl)-5-methyl-6-oxo-6-dihydro-5H-imidazo[1,2-a]imidazole-3-carboxylic acid {1-[1-(5-iodo-pyrimidin-2-yl)-cyclopropylcarbamoyl]-cyclopropyl}-amide 
• 1159735-91-7 (R)-5-(4-cyano-benzyl)-7-(3,5-dichloro-4-fluoro-phenyl)-5-methyl-6-oxo-6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-carbonyl chloride 
• 1159735-63-3 (R)-2-(4-cyano-phenyl)-1-(3,5-dichloro-4-fluoro-phenylcarbamoyl)-1-methyl-ethyl-ammonium toluene-4-sulfonate 
• 1159735-59-7 4-[(2R,4R)-2-tert-butyl-1-(3,5-dichloro-4-fluoro-phenyl)-4-methyl-5-oxo-3-(2,2,2-trifluoro-acetyl)-imidazolidin-4-ylmethyl]-benzonitrile 
• 1159735-65-5 (R)-3-(4-cyano-phenyl)-N-(3,5-dichloro-4-fluoro-phenyl)-2-[3-(2,2-dimethoxy-ethyl)-ureido]-2-methyl-propionamide 
• 1159735-71-3 (R)‐5‐(4‐cyanobenzyl)‐7‐(3,5‐dichloro‐4‐fluorophenyl)‐5‐methyl‐6‐oxo‐6,7‐dihydro‐5H‐imidazo[1,2‐a]imidazole‐3‐carboxylic acid 
• 1159735-69-9 (R)‐4‐((1‐(3,5‐dichloro‐4‐fluorophenyl)‐5‐iodo‐3‐methyl‐2‐oxo‐2,3‐dihydro‐1H‐imidazo[1,2‐a]imidazol‐3‐yl)methyl)benzonitrile 
• 1159735-67-7 4-[(R)-1-(3,5-dichloro-4-fluoro-phenyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[1,2-a]imidazol-3-ylmethyl]-benzonitrile 
• 1159735-57-5 (2S,5R)-2-tert-butyl-3-(3,5-dichloro-4-fluoro-phenyl)-5-methyl-1-(2,2,2-trifluoro-acetyl)-imidazolidin-4-one 
• 1159735-55-3 (2S,5R)-2-tert-butyl-3-(3,5-dichloro-4-fluoro-phenyl)-5-methyl-imidazolidin-4-one 
• 1159735-53-1 (R)-2-amino-N-(3,5-dichloro-4-fluoro-phenyl)-propionamide 

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