27330-35-4

Basic information

• Product Name: Ethyl 3-aMino-5-chloropicolinate
• Synonyms: Ethyl 3-aMino-5-chloropicolinate;3-Amino-5-chloro-2-pyridinecarboxylic acid ethyl ester;NSC 151928;3-Amino-5-chloro-pyridine-2-carboxylic acid ethyl ester
• CAS NO: 27330-35-4
• Molecular Formula: C₈H₉ClN₂O₂
• Molecular Weight: 200.62226
• EINECS: -0
• Mol File: 27330-35-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 345.9°C at 760 mmHg
• Flash Point: 163°C
• Appearance: /
• Density: 1.326g/cm³
• Vapor Pressure: 5.97E-05mmHg at 25°C
• Refractive Index: 1.573
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 0.51±0.10(Predicted)
• CAS DataBase Reference: Ethyl 3-aMino-5-chloropicolinate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 3-aMino-5-chloropicolinate(27330-35-4)
• EPA Substance Registry System: Ethyl 3-aMino-5-chloropicolinate(27330-35-4)

Safety Data

• Hazardous Substances Data: 27330-35-4(Hazardous Substances Data)

Usage

General Description

Ethyl 3-amino-5-chloropicolinate is a chemical compound with the molecular formula C8H8ClNO2. It is a derivative of picolinic acid and contains an ethyl group, an amino group, and a chlorine atom. Ethyl 3-aMino-5-chloropicolinate is commonly used in the synthesis of pharmaceuticals and agrochemicals. It is also a key intermediate in the production of various organic compounds. Ethyl 3-amino-5-chloropicolinate has potential applications in the field of medicinal chemistry and is being researched for its biological activity and potential use as a therapeutic agent. However, it is important to handle this compound with caution as it may pose health hazards if not handled properly.

InChI:InChI=1/C8H9ClN2O2/c1-2-13-8(12)7-6(10)3-5(9)4-11-7/h3-4H,2,10H2,1H3

Upstream product

• 5409-39-2 2-amino-5-chloro-3-nitropyridine 
• 181123-11-5 5-chloro-2-cyano-3-nitropyridine 
• 75806-86-9 2-bromo-5-chloro-3-nitropyridine 
• 27330-34-3 3-amino-5-chloropicolinamide 
• 1072-98-6 5-chloro-2-pyridylamine 
• 64-17-5 ethanol 

Downstream Products

• 372951-26-3 5-chloro-3-[2-(3-nitro-phenyl)-acetylamino]-pyridine-2-carboxylic acid ethyl ester 
• 181123-13-7 ethyl 3-(m-phenoxyphenyl)acetylamido-5-chloropicolinate 
• 372951-22-9 ethyl 3-(p-chloro)phenylacetylamido-5-chloropicolinate 
• 212378-47-7 ethyl 3-phenylacetylamido-5-chloropicolinate 
• 372951-23-0 ethyl 3-(m-chloro)phenylacetylamido-5-chloropicolinate 
• 372951-24-1 ethyl 3-(o-chloro)phenylacetylamido-5-chloropicolinate 
• 181123-12-6 ethyl 3-(m-methoxy)phenylacetylamido-5-chloropicolinate 
• 372951-25-2 ethyl 3-(m-methyl)phenylacetylamido-5-chloropicolinate 
• 181122-94-1 ACEA 762 

Relevant articles and documents

Synthesis and SAR of 5-, 6-, 7- and 8-aza analogues of 3-aryl-4-hydroxyquinolin-2(1H)-one as NMDA/glycine site antagonists

A series of 5-, 6-, 7- and 8-aza analogues of 3-aryl-4-hydroxyquinolin-2(1H)-one was synthesized and assayed as NMDA/glycine receptor antagonists. The in vitro potency of these antagonists was determined by displacement of the glycine site radioligand [3H]5,7-dicholorokynurenic acid ([3H]DCKA) in rat brain cortical membranes. Selected compounds were also tested for functional antagonism using electrophysiological assays in Xenopus oocytes expressing cloned NMDA receptor (NR) 1A/2C subunits. Among the 5-, 6-, 7-, and 8-aza-3-aryl-4-hydroxyquinoline-2(1H)-ones investigated, 5-aza-7-chloro-4-hydroxy-3-(3-phenoxyphenyl)quinolin-2-(1H)-one (13i) is the most potent antagonist, having an IC50 value of 110 nM in [3H]DCKA binding and a Kb of 11 nM in the electrophysiology assay. Compound 13i is also an active anticonvulsant when administered systemically in the mouse maximum electroshock-induced seizure test (ED50 = 2.3 mg/kg, IP).