273399-94-3

Basic information

• Product Name: (S)-FMOC-3-AMINO-2-(PHENYLSULFONYLAMINO)-PROPIONIC ACID
• Synonyms: FMOC-(S)-3-AMINO-2-(PHENYLSULFONYLAMINO)-PROPIONIC ACID;(S)-FMOC-3-AMINO-2-(PHENYLSULFONYLAMINO)-PROPIONIC ACID
• CAS NO: 273399-94-3
• Molecular Formula: C₂₄H₂₂N₂O₆S
• Molecular Weight: 466.51
• Mol File: 273399-94-3.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Density: 1.381±0.06 g/cm3(Predicted)
• Storage Temp.: Store at?0-5°C
• PKA: 3.12±0.10(Predicted)
• CAS DataBase Reference: (S)-FMOC-3-AMINO-2-(PHENYLSULFONYLAMINO)-PROPIONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-FMOC-3-AMINO-2-(PHENYLSULFONYLAMINO)-PROPIONIC ACID(273399-94-3)
• EPA Substance Registry System: (S)-FMOC-3-AMINO-2-(PHENYLSULFONYLAMINO)-PROPIONIC ACID(273399-94-3)

Safety Data

• Hazardous Substances Data: 273399-94-3(Hazardous Substances Data)

Usage

Description

(S)-FMOC-3-AMINO-2-(PHENYLSULFONYLAMINO)-PROPIONIC ACID is a chemical compound with the molecular formula C23H20N2O5S. It is a derivative of the amino acid proline, featuring a sulfonamide group and a fluorinated benzene ring. (S)-FMOC-3-AMINO-2-(PHENYLSULFONYLAMINO)-PROPIONIC ACID is characterized by its unique structure, which allows it to be a versatile building block in the synthesis of peptide molecules.

Uses

Used in Pharmaceutical Industry:
(S)-FMOC-3-AMINO-2-(PHENYLSULFONYLAMINO)-PROPIONIC ACID is used as a building block for the synthesis of peptide molecules, particularly in the development of new drugs. Its incorporation into peptide structures can potentially enhance the pharmacological properties of these drugs, making them more effective in treating various medical conditions.
Used in Research and Development:
In the field of peptide chemistry, (S)-FMOC-3-AMINO-2-(PHENYLSULFONYLAMINO)-PROPIONIC ACID is used as a key component in the design and synthesis of novel peptide-based compounds. Its unique structural features enable researchers to explore new avenues in drug discovery and the development of bioactive molecules with specific therapeutic applications.
Used in Solid-Phase Peptide Synthesis:
(S)-FMOC-3-AMINO-2-(PHENYLSULFONYLAMINO)-PROPIONIC ACID is used as a protected amino acid in solid-phase peptide synthesis. The FMOC protecting group shields the amino group from unwanted reactions, allowing for the stepwise assembly of peptide chains with greater precision and control. This technique is crucial for the efficient production of complex peptide molecules with specific sequences and functions.
Used in Structural Biology:
The sulfonamide group in (S)-FMOC-3-AMINO-2-(PHENYLSULFONYLAMINO)-PROPIONIC ACID can form hydrogen bonds, which may contribute to the structural and functional properties of the peptides it is incorporated into. This feature makes it a valuable tool in structural biology, where understanding the three-dimensional architecture of proteins and their interactions with other molecules is essential for elucidating biological processes and developing targeted therapeutic strategies.

Upstream product

• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 
• 156185-88-5 3-amino-2(S)-phenylsulfonylaminopropionic acid 

Relevant articles and documents

BENZIMIDAZOLE COMPOUNDS THAT ARE VITRONECTIN RECEPTOR ANTAGONISTS

The present invention provides compounds having formula (I) wherein n, p, q and r are each independently selected from 0 or 1; a, b, c, and d each independently represents a carbon or nitrogen atom, with the proviso that no more than two of a, b, c, and d are nitrogen atoms; Y and Y' each independently represents 1-4 optional substituents selected from alkyl, alkoxy, halo, -CF3, and -C(O)OH; R, R, R and R are H or specified substituents; R, R, R, R, R, R, R and R are independently selected from H or C1-C3 alkyl; or a biolabile ester thereof, or a pharmaceutically acceptable salt thereof. Also provided are methods of using these compounds for treating vitronectin-mediated disorders, e.g., cancer, retinopathy, artherosclerosis, vascular restenosis, and osteoporosis.