27383-91-1Relevant articles and documents
Ag(I)-Catalyzed C-H Carboxylation of Thiophene Derivatives
Lee, Mijung,Hwang, Young Kyu,Kwak, Jaesung
, p. 3136 - 3144 (2021/09/30)
CO2utilization is an attractive aspect as it allows the direct conversion of CO2into valuable chemicals. In this regard, direct incorporation of CO2into the C-H bond of heteroaromatic compounds is important due to the ubiquitous structural motifs of the heteroaromatic carboxylic acids. Herein, we report the Ag-catalyzed C-H carboxylation of thiophene derivatives. This new catalytic system involving a phosphine ligand and lithiumtert-butoxide enables the direct carboxylation of thiophenes under mild reaction conditions. Experimental studies revealed that the use oftert-butyl alkoxide is critical for the exergonic formation of an arylsilver intermediate, and the results were further supported by density functional theory calculations.
Method of synthesizing heteroaromatic formic ether compound
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Paragraph 0040, (2017/08/19)
The invention discloses a method of synthesizing a heteroaromatic formic ether compound. By taking midazolium chloride salt of which the molecular formula is [(ArN=C(CH3)NCH2CH2NCH2C6H5)CH]Cl (wherein Ar is equal to 2,6-bi-CH(CH3)2-C6H3) as a catalyst, the heteroaromatic formic ether compound is synthesized through carboxylation reaction of a heteroaromatic compound and carbon dioxide at atmospheric pressure. The heteroaromatic formic ether compound is a first example that is catalyzed by imidazolium salt and prepared through the carboxylation reaction of the heteroaromatic compound and carbon dioxide. Compared with the prior art, the catalyst is green, the synthesis is easier, reaction conditions are mild, and the heteroaromatic formic ether compound has equivalent or better catalytic activity and functional group tolerance.
PH-Responsive N-heterocyclic carbene copper(i) complexes: Syntheses and recoverable applications in the carboxylation of arylboronic esters and benzoxazole with carbon dioxide
Wang, Wenlong,Zhang, Guodong,Lang, Rui,Xia, Chungu,Li, Fuwei
supporting information, p. 635 - 640 (2013/03/29)
A pH-controlled monophasic/biphasic switchable system has been developed as a green and novel strategy for homogeneous catalyst recycling, which has been successfully applied to the Cu-NHC-catalyzed carboxylation of organoboronic esters and benzoxazole with carbon dioxide. Additionally, the present strategy could also be extended to the Ag-NHC-catalyzed carboxylation of terminal alkyne. The tertiary amine-functionalized catalysts could be used for at least four times with a slight loss of activity.