2739-98-2

Basic information

• Product Name: Ethyl 2-pyridylacetate
• Synonyms: Ethyl (pyridin-2-yl)acetate;Ethyl 2-pyridylacetate, 98% 5GR;Ethyl 2-Pyridineacetate 2-Pyridylacetic Acid Ethyl Ester 2-Pyridineacetic Acid Ethyl Ester;Ethyl 2-pyridylacetate 98%;2-PYRIDINEACETIC ACID ETHYL ESTER;2-PYRIDYLACETIC ACID ETHYL ESTER;ETHYL PYRIDINE-2-ACETATE;ETHYL 2-PYRIDIN-2-YLACETATE
• CAS NO: 2739-98-2
• Molecular Formula: C₉H₁₁NO₂
• Molecular Weight: 165.19
• EINECS: 220-365-1
• Product Categories: Building Blocks;C8 to C9;Chemical Synthesis;Heterocyclic Building Blocks;Pyridines;Acetics acid and esters
• Mol File: 2739-98-2.mol
• Article Data: 16

Chemical Properties

• Melting Point: 136-137 °C
• Boiling Point: 70 °C0.05 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: Clear yellow/Liquid
• Density: 1.084 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.00104mmHg at 25°C
• Refractive Index: n20/D 1.497(lit.)
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 4.45±0.12(Predicted)
• Water Solubility: Soluble in water.
• BRN: 123817
• CAS DataBase Reference: Ethyl 2-pyridylacetate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 2-pyridylacetate(2739-98-2)
• EPA Substance Registry System: Ethyl 2-pyridylacetate(2739-98-2)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36-37/39
• WGK Germany: 3
• Hazardous Substances Data: 2739-98-2(Hazardous Substances Data)

Usage

Description

Ethyl 2-pyridylacetate is a clear yellow liquid that serves as an essential raw material and intermediate in various chemical processes. It is widely utilized in the synthesis of organic compounds, pharmaceuticals, agrochemicals, and dyestuffs due to its unique chemical properties.

Uses

Used in Organic Synthesis:
Ethyl 2-pyridylacetate is used as a key intermediate for the synthesis of various organic compounds. Its chemical structure allows for the creation of a diverse range of molecules, making it a valuable asset in the field of organic chemistry.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Ethyl 2-pyridylacetate is used as a crucial building block for the development of new drugs. Its unique properties enable the design and synthesis of novel therapeutic agents, contributing to the advancement of medical treatments.
Used in Agrochemicals:
Ethyl 2-pyridylacetate plays a significant role in the agrochemical industry, where it is employed as a starting material for the synthesis of various agrochemical products. Its use in this sector helps in the development of more effective and environmentally friendly solutions for agricultural applications.
Used in Dyestuff Industry:
In the dyestuff industry, Ethyl 2-pyridylacetate is used as an intermediate for the production of different types of dyes. Its versatility in chemical reactions allows for the creation of a wide array of colorants, catering to the diverse needs of the dyestuff market.

InChI:InChI=1/C9H11NO2/c1-2-12-9(11)7-8-5-3-4-6-10-8/h3-6H,2,7H2,1H3

Upstream product

• 93617-73-3 2-Ethoxycarbonylmethyl-2H-pyridine-1-carboxylic acid phenyl ester 
• 109-04-6 2-bromo-pyridine 
• 105-53-3 diethyl malonate 
• 109-09-1 2-chloropyridine 
• 5764-82-9 bromo(2-ethoxy-2-oxoethyl)zinc 
• 64-17-5 ethanol 
• 1620-53-7 1-phenyl-2-pyridin-2-ylethanone 
• 61890-12-8 1-phenyl-2-[2]pyridyl-ethanone-(E)-oxime 
• 6959-47-3 2-chloromethylpyridine hydrochloride 
• 110-86-1 pyridine 
• 5029-67-4 2-iodopyridine 
• 6148-64-7 ethyl potassium malonate 
• 1749-29-7 2-pyridylmethyllithium 
• 124-38-9 carbon dioxide 

Downstream Products

• 223717-85-9 3-(benzyloxycarbonyl)amino-1-ethoxycarbonyl-4H-pyrido[1,2-a]pyridin-4-one 
• 13115-43-0 2-pyridineacetic acid 
• 64-17-5 ethanol 
• 943-16-8 2-(2-ethoxy-2-oxoethyl)-1-methylpyridin-1-ium iodide 
• 131602-99-8 2-(2-pyridyl)-3-oxo-3,4-dihydro-2H-1,4-benzothiazine 
• 137-07-5 2-amino-benzenethiol 
• 133604-84-9 3,5-dimethylphenyl 2-pyridylacetate 
• 116655-53-9 (2,4-Dinitro-phenyl)-pyridin-2-yl-acetic acid ethyl ester 
• 93545-36-9 2-(Diethoxyphosphinyl)-3-phenyl-1-indolizincarbonsaeure-ethylester 
• 89021-18-1 3-<(Diisopropoxyphosphinyl)hydroxymethyl>-2-phenyl-1-indolizincarbonsaeure-ethylester 
• 119540-43-1 3-[1-(4-Methoxy-phenyl)-5-p-tolyl-1H-pyrazol-3-yl]-2-pyridin-2-yl-propionic acid ethyl ester 
• 95474-00-3 4-hydroxy-1-phenyl-3-(2-pyridyl)-1,8-naphthyridin-2(1H)one 
• 129957-59-1 3-(4-Chlorphenyl)-1-ethoxycarbonyl-2-hydroxy-4-oxo-4H-chinolizin 
• 103825-72-5 7-(N-Phenylsulfonyl)amino-3-(2-pyridyl)coumarin 

Relevant articles and documents

Copper-Catalyzed Ullmann-Type Coupling and Decarboxylation Cascade of Arylhalides with Malonates to Access α-Aryl Esters

We have developed a high-efficiency and practical Cu-catalyzed cross-coupling to directly construct versatile α-aryl-esters by utilizing readily available aryl bromides (or chlorides) and malonates. These gram-scale approaches occur with turnovers of up to 1560 and are smoothly conducted by the usage of a low catalyst loading, a new available ligand, and a green solvent. A variety of functional groups are tolerated, and the application occurs with α-aryl-esters to access nonsteroidal anti-inflammatory drugs (NSAIDs) on the gram scale.

Coupling of Reformatsky Reagents with Aryl Chlorides Enabled by Ylide-Functionalized Phosphine Ligands

The coupling of aryl chlorides with Reformatsky reagents is a desirable strategy for the construction of α-aryl esters but has so far been substantially limited in the substrate scope due to many challenges posed by various possible side reactions. This limitation has now been overcome by the tailoring of ylide-functionalized phosphines to fit the requirements of Negishi couplings. Record-setting activities were achieved in palladium-catalyzed arylations of organozinc reagents with aryl electrophiles using a cyclohexyl-YPhos ligand bearing an ortho-tolyl-substituent in the backbone. This highly electron-rich, bulky ligand enables the use of aryl chlorides in room temperature couplings of Reformatsky reagents. The reaction scope covers diversely functionalized arylacetic and arylpropionic acid derivatives. Aryl bromides and chlorides can be converted selectively over triflate electrophiles, which permits consecutive coupling strategies.

A One-Pot Sonogashira Coupling and Annulation Reaction: An Efficient Route toward 4 H -Quinolizin-4-ones

An efficient one-pot Sonogashira coupling and annulation reaction affording 4 H -quinolizin-4-ones in moderate to excellent yields is described. A variety of substituted iodoarenes and 2-alkylazaarenes were well tolerated, and especially the unsaturated double and triple bonds were compatible under the standard conditions.