27398-50-1

Basic information

• Product Name: 6-BROMO-2-PHENYL-1H-QUINAZOLIN-4-ONE
• Synonyms: 6-BROMO-2-PHENYL-1H-QUINAZOLIN-4-ONE;6-broMo-2-phenylquinazolin-4(3H)-one;4(1H)-Quinazolinone, 6-broMo-2-phenyl-;6-broMo-2-phenyl-3,4-dihydroquinazolin-4-one;6-Bromo-2-phenyl-3H-quinazolin-4-one
• CAS NO: 27398-50-1
• Molecular Formula: C₁₄H₉BrN₂O
• Molecular Weight: 301.14
• Mol File: 27398-50-1.mol
• Article Data: 44

Chemical Properties

• Melting Point: 303-305 °C(Solv: isopropanol (67-63-0))
• Boiling Point: 455.5±47.0 °C(Predicted)
• Appearance: /
• Density: 1.57 g/cm³
• PKA: 6.08±0.20(Predicted)
• CAS DataBase Reference: 6-BROMO-2-PHENYL-1H-QUINAZOLIN-4-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-BROMO-2-PHENYL-1H-QUINAZOLIN-4-ONE(27398-50-1)
• EPA Substance Registry System: 6-BROMO-2-PHENYL-1H-QUINAZOLIN-4-ONE(27398-50-1)

Safety Data

• Hazardous Substances Data: 27398-50-1(Hazardous Substances Data)

Upstream product

• 39263-32-6 2-amino-5-bromobenzonitrile 
• 100-51-6 benzyl alcohol 
• 1670-14-0 benzamidine monohydrochloride 
• 189635-01-6 N-(4-bromo-2-cyanophenyl)benzamide 
• 639482-27-2 2-benzamido-5-bromobenzamide 
• 98-88-4 benzoyl chloride 
• 16313-66-9 5-bromoanthranilamide 
• 100-52-7 benzaldehyde 
• 28144-70-9 anthranilic acid amide 
• 100-46-9 benzylamine 
• 144-62-7 oxalic acid 
• 100-44-7 benzyl chloride 
• 1397833-71-4 (2-amino-5-bromophenyl) (benzotriazole-1-yl)methanone 
• 707-07-3 orthobenzoic acid trimethyl ester 

Downstream Products

• 412923-42-3 6-bromo-4-chloro-2-phenyl-quinazoline 
• 1257629-22-3 [(6-bromo-2-phenyl-4-quinazolinyl)oxy]-acetyl hydrazine 
• 1257629-15-4 C₂₀H₁₅BrN₄O₃ 
• 1257629-17-6 6-bromo-4-(1,3,4-oxadiazol-2-ylmethoxy)-2-phenylquinazoline 
• 1257629-18-7 5-{[(6-bromo-2-phenylquinazolin-4-yl)oxy]methyl}-1,3,4-oxadiazol-2(3H)-thione 
• 1257629-20-1 5-{[(6-bromo-2-phenylquinazolin-4-yl)oxy]methyl}-2,4-dihydro-3H-1,2,4-triazol-3-thione 
• 1257629-21-2 C₁₈H₁₅BrN₂O₃ 
• 1332259-69-4 potassium 2-({4-[(6-bromo-2-phenylquinazoline-4-yl)amino]phenyl}carbonyl)hydrazine carbodithioic acid 

Relevant articles and documents

Linear-Organic-Polymer-Supported Iridium Complex as a Recyclable Auto-Tandem Catalyst for the Synthesis of Quinazolinones via Selective Hydration/Acceptorless Dehydrogenative Coupling from o-Aminobenzonitriles

A linear-organic-polymer-supported iridium complex Cp*Ir@P4VP, which is designed and synthesized by the coordinative immobilization of [Cp*IrCl2]2 on poly(4-vinylpyridine), was proven to be an efficient heterogeneous autotandem catalyst for synthesizing quinazolinones via selective hydration/acceptorless dehydrogenative coupling from o-aminobenzonitriles. Furthermore, the synthesized catalyst was recycled five times without an obvious decrease in the catalytic activity.

Preparation method of quinazolinone derivative

The invention discloses a preparation method of a quinazolinone derivative, wherein the preparation method comprises the following steps: dissolving an anthranilonitrile compound represented by a formula I and an aldehyde represented by a formula II in a

Regioselective Synthesis of 2° Amides Using Visible-Light-Induced Photoredox-Catalyzed Nonaqueous Oxidative C-N Cleavage of N, N-Dibenzylanilines

A visible-light-driven photoredox-catalyzed nonaqueous oxidative C-N cleavage of N,N-dibenzylanilines to 2° amides is reported. Further, we have applied this protocol on 2-(dibenzylamino)benzamide to afford quinazolinones with (NH4)2S2O8 as an additive. Mechanistic studies imply that the reaction might undergo in situ generation of α-amino radical to imine by C-N bond cleavage followed by the addition of superoxide ion to form amides.