27432-39-9

Basic information

• Product Name: 1-(2-methoxyphenyl)butan-2-one
• Synonyms: 1-(2-methoxyphenyl)butan-2-one;1-(2-Methoxyphenyl)-2-butanone
• CAS NO: 27432-39-9
• Molecular Formula: C₁₁H₁₄O₂
• Molecular Weight: 178.22766
• EINECS: 248-457-7
• Mol File: 27432-39-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 256.9°Cat760mmHg
• Flash Point: 101.6°C
• Appearance: /
• Density: 1.01g/cm³
• Vapor Pressure: 0.015mmHg at 25°C
• Refractive Index: 1.498
• CAS DataBase Reference: 1-(2-methoxyphenyl)butan-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-methoxyphenyl)butan-2-one(27432-39-9)
• EPA Substance Registry System: 1-(2-methoxyphenyl)butan-2-one(27432-39-9)

Safety Data

• Hazardous Substances Data: 27432-39-9(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Tetrahedron Letters, 26, p. 2273, 1985 DOI: 10.1016/S0040-4039(00)95072-X

InChI:InChI=1/C11H14O2/c1-3-10(12)8-9-6-4-5-7-11(9)13-2/h4-7H,3,8H2,1-2H3

Upstream product

• 93-25-4 2-methoxyphenylacetic acid 
• 3343-80-4 (2-ethylbenzofuran-3-yl)(4-methoxyphenyl)methanone 
• 3131-64-4 (2-ethylbenzofuran-3-yl)(phenyl)methanone 
• 74-88-4 methyl iodide 
• 529-28-2 4-iodoanisol 
• 78-93-3 butanone 
• 28033-63-8 2-(2-methoxyphenyl)acetyl chloride 
• 999-75-7 ethylzinc iodide 

Downstream Products

• 18272-72-5 1-butyl-2-methoxybenzene 
• 3180-09-4 ortho-butylphenol 
• 663189-42-2 3-(2-methoxy-benzyl)-valeric acid 
• 663189-15-9 3-ethyl-5-methoxy-3,4-dihydro-2H-naphthalen-1-one 

Relevant articles and documents

Novel synthesis of benzofuran- and indol-2-yl-methanamine derivatives

We report on a novel synthesis towards benzofuran-2-yl-methanamine and indol-2-yl-methanamine derivatives by using ortho-methoxy and ortho-nitro substituted phenylacetic acids as starting material, respectively. For each compound series, a key intermediate bearing the oxazole-4-carboxylic acid methylester moiety was produced. Refluxing the ortho-methoxy series in HBr/HAc produced the desired benzofuran-2-yl-methanamines. Accordingly, for the synthesis of indoles the nitro-group was first reduced and refluxing these intermediates in HCl gave the corresponding indol-2-yl-methanamines. The method worked well with electron donating substituents. Limitations regarding electron withdrawing substituents are discussed. This straightforward synthetic procedure can be a useful approach to generate a variety of substituted benzofuran-2-yl-methanamine and indol-2-yl-methanamine compounds by starting from readily available phenylacetic acid derivatives.

Hypocholesteremic agents. I. Substituted stilbazoles and dihydrostilbazoles.

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