27460-33-9Relevant articles and documents
Efficient, stereoselective synthesis of 24(s), 25-epoxycholesterol
Tomkinson, Nicholas C. O.,Willson, Timothy M.,Russel, Jonathon S.,Spencer, Thomas A.
, p. 9919 - 9923 (2007/10/03)
Efficient, stereoselective syntheses of 24(S), 25-epoxycholesterol (1) have been developed starting from cholenic acid (4) or stigmasterol (8), both featuring as the key step Sharpless asymmetric dihydroxylation of desmosterol acetate (2). This work permits preparation of gram quantities of 1 for further evaluation as a natural regulator of cholesterol metabolism, specifically, e.g., as a ligand for the LXRα. nuclear receptor.