27471-36-9Relevant articles and documents
Preparation method of apixaban and intermediate thereof
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Paragraph 0112-0116, (2019/08/06)
The invention relates to a preparation method of apixaban (an antithrombotic drug) and a related intermediate, The preparation method comprises the specific steps as follows: carrying out amidation-cyclization integrated reaction on p-nitroaniline, which
New synthetic routes for N-substituted 1,n-diamines. II. Synthesis of selectively N-substituted tetra- and pentamethylenediamines from ω-alkanoic acid derivatives
Ramírez, María A.,Corona, María V.,Ortiz, Gisela,Salerno, Alejandra,Perillo, Isabel A.,Blanco, María M.
supporting information; experimental part, p. 1466 - 1468 (2011/06/10)
A new approach for the synthesis of selectively N-substituted tetra- and pentamethylenediamines 1 (n = 4,5) is described. The method uses N-substituted ω-haloalkanamides 2 as precursors and involves the microwave-promoted conversion into ω-azidocarboxamides 3 and later the reduction of both azido and carboxamide groups with diborane.