274925-56-3

Basic information

• Product Name: 3-BroMo-5,6-dihydrobenzo[b]thiophen-7(4H)-one
• Synonyms: 3-BroMo-5,6-dihydrobenzo[b]thiophen-7(4H)-one
• CAS NO: 274925-56-3
• Molecular Formula: C8H7BrOS
• Molecular Weight: 231.113
• Mol File: 274925-56-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-BroMo-5,6-dihydrobenzo[b]thiophen-7(4H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BroMo-5,6-dihydrobenzo[b]thiophen-7(4H)-one(274925-56-3)
• EPA Substance Registry System: 3-BroMo-5,6-dihydrobenzo[b]thiophen-7(4H)-one(274925-56-3)

Safety Data

• Hazardous Substances Data: 274925-56-3(Hazardous Substances Data)

Upstream product

• 1468-84-4 5,6-dihydro-4H-benzothiophen-7-one 

Relevant articles and documents

Preparation of thieno[3,2-h]cinnolinones as matrix metalloproteinase inhibitors

A new series of thieno[3,2-h]cinnolinone analogues was synthesized which is structurally related to 2,3,4,4a,5,6-hexahydrothieno[3,2-h]cinnolin-3-one 1, a weak inhibitor of the matrix metalloproteinase MMP-8 (human neutrophil collagenase). Preliminary SAR studies have shown that while C(4a)-methyl, C7-acetylamino, C7 and C8-nitro substitution, and C4-C(4a) olefination provided no increase in activity relative to 1, C8-acetylamino substitution as in 5 and 8 was favourable. Moreover, to predict how the thieno[3,2- h]cinnolinone inhibitors might bind to MMP-8, the unsubstituted compound 9 was docked into the MMP-8 crystal structure. These studies revealed that inhibitor 9 does not seem to be able to coordinate the catalytically-active zinc ion but preferably interact with the peptide-binding region of the active site.